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Putting Together Pieces of the Lateral Septum: Multifaceted Functions and Its Neural Pathways

The lateral septum (LS) is implicated as a hub that regulates a variety of affects, such as reward, feeding, anxiety, fear, sociability, and memory. However, it remains unclear how the LS, previously treated as a structure of homogeneity, exhibits such multifaceted functions. Emerging evidence sugge...

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Detalles Bibliográficos
Autores principales: Rizzi-Wise, Candace A., Wang, Dong V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Society for Neuroscience 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8647703/
https://www.ncbi.nlm.nih.gov/pubmed/34764187
http://dx.doi.org/10.1523/ENEURO.0315-21.2021
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author Rizzi-Wise, Candace A.
Wang, Dong V.
author_facet Rizzi-Wise, Candace A.
Wang, Dong V.
author_sort Rizzi-Wise, Candace A.
collection PubMed
description The lateral septum (LS) is implicated as a hub that regulates a variety of affects, such as reward, feeding, anxiety, fear, sociability, and memory. However, it remains unclear how the LS, previously treated as a structure of homogeneity, exhibits such multifaceted functions. Emerging evidence suggests that different functions of the LS are mediated largely by its diverse input and output connections. It has also become clear that the LS is a heterogeneous region, where its dorsal and ventral poles play dissociable and often opposing roles. This functional heterogeneity can often be explained by distinct dorsal and ventral hippocampal inputs along the LS dorsoventral axis, as well as antagonizing connections between LS subregions. Similarly, outputs from LS subregions to respective downstream targets, such as hypothalamic, preoptic, and tegmental areas, also account for this functional heterogeneity. In this review, we provide an updated perspective on LS subregion classification, connectivity, and functions. We also identify key questions that have yet to be addressed in the field.
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spelling pubmed-86477032021-12-07 Putting Together Pieces of the Lateral Septum: Multifaceted Functions and Its Neural Pathways Rizzi-Wise, Candace A. Wang, Dong V. eNeuro Review The lateral septum (LS) is implicated as a hub that regulates a variety of affects, such as reward, feeding, anxiety, fear, sociability, and memory. However, it remains unclear how the LS, previously treated as a structure of homogeneity, exhibits such multifaceted functions. Emerging evidence suggests that different functions of the LS are mediated largely by its diverse input and output connections. It has also become clear that the LS is a heterogeneous region, where its dorsal and ventral poles play dissociable and often opposing roles. This functional heterogeneity can often be explained by distinct dorsal and ventral hippocampal inputs along the LS dorsoventral axis, as well as antagonizing connections between LS subregions. Similarly, outputs from LS subregions to respective downstream targets, such as hypothalamic, preoptic, and tegmental areas, also account for this functional heterogeneity. In this review, we provide an updated perspective on LS subregion classification, connectivity, and functions. We also identify key questions that have yet to be addressed in the field. Society for Neuroscience 2021-12-02 /pmc/articles/PMC8647703/ /pubmed/34764187 http://dx.doi.org/10.1523/ENEURO.0315-21.2021 Text en Copyright © 2021 Rizzi-Wise and Wang https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.
spellingShingle Review
Rizzi-Wise, Candace A.
Wang, Dong V.
Putting Together Pieces of the Lateral Septum: Multifaceted Functions and Its Neural Pathways
title Putting Together Pieces of the Lateral Septum: Multifaceted Functions and Its Neural Pathways
title_full Putting Together Pieces of the Lateral Septum: Multifaceted Functions and Its Neural Pathways
title_fullStr Putting Together Pieces of the Lateral Septum: Multifaceted Functions and Its Neural Pathways
title_full_unstemmed Putting Together Pieces of the Lateral Septum: Multifaceted Functions and Its Neural Pathways
title_short Putting Together Pieces of the Lateral Septum: Multifaceted Functions and Its Neural Pathways
title_sort putting together pieces of the lateral septum: multifaceted functions and its neural pathways
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8647703/
https://www.ncbi.nlm.nih.gov/pubmed/34764187
http://dx.doi.org/10.1523/ENEURO.0315-21.2021
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