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N-tert-Butyl-2-{2-[2-(4-chloro­phen­yl)-4-hy­droxy-1-(5-methyl­isoxazol-3-yl)-5-oxo-2,5-di­hydro-1H-pyrrol-3-yl]-N-(4-meth­oxy­phen­yl)acetamido}-2-(4-meth­oxy­phen­yl)acetamide methanol monosolvate: single-crystal X-ray diffraction study and Hirshfeld surface analysis

The title compound, C(36)H(37)ClN(4)O(7)·CH(3)OH, which crystallizes as a methanol solvate, may possess biological activity, which is inherent for a natural peptide or protein. In the crystal, mol­ecules of the title compound form hydrogen-bonded tetra­mers with the solvate mol­ecules acting as brid...

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Detalles Bibliográficos
Autores principales: Shyshkina, Mariia O., Sakhno, Yana I., Radchenko, Oleksandr V., Shishkina, Svitlana V., Desenko, Sergey M., Chebanov, Valentyn A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Union of Crystallography 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8647747/
https://www.ncbi.nlm.nih.gov/pubmed/34925883
http://dx.doi.org/10.1107/S2056989021011312
Descripción
Sumario:The title compound, C(36)H(37)ClN(4)O(7)·CH(3)OH, which crystallizes as a methanol solvate, may possess biological activity, which is inherent for a natural peptide or protein. In the crystal, mol­ecules of the title compound form hydrogen-bonded tetra­mers with the solvate mol­ecules acting as bridges as a result of the O—H⋯O and N—H⋯O inter­molecular hydrogen bonds. Hirshfeld surface analysis was used to study the different types of inter­molecular inter­actions whose contributions are: H⋯H = 53.8%, O⋯H/H⋯O = 19.0%, C⋯H/H⋯C = 14.8%, Cl⋯H/H⋯Cl = 5.3%, N⋯H/H⋯N = 3.2%.