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Hypofractionated Preoperative Radiotherapy for High Risk Soft Tissue Sarcomas in a Geriatric Patient Population
BACKGROUND: Standard therapy for localised, resectable high risk soft tissue sarcomas consists of wide excision and radiotherapy over several weeks. This treatment schedule is hardly feasible in geriatric and frail patients. In order not to withhold radiotherapy from these patients, hypofractionated...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Sciendo
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8647799/ https://www.ncbi.nlm.nih.gov/pubmed/34821137 http://dx.doi.org/10.2478/raon-2021-0038 |
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author | Potkrajcic, Vlatko Traub, Frank Hermes, Barbara Scharpf, Marcus Kolbenschlag, Jonas Zips, Daniel Paulsen, Frank Eckert, Franziska |
author_facet | Potkrajcic, Vlatko Traub, Frank Hermes, Barbara Scharpf, Marcus Kolbenschlag, Jonas Zips, Daniel Paulsen, Frank Eckert, Franziska |
author_sort | Potkrajcic, Vlatko |
collection | PubMed |
description | BACKGROUND: Standard therapy for localised, resectable high risk soft tissue sarcomas consists of wide excision and radiotherapy over several weeks. This treatment schedule is hardly feasible in geriatric and frail patients. In order not to withhold radiotherapy from these patients, hypofractionated radiotherapy with 25 Gy in 5 fractions was evaluated in a geriatric patient population. PATIENTS AND METHODS: A retrospective analysis was performed of 18 geriatric patients with resectable high risk soft tissue sarcomas of extremities and thoracic wall. Wound healing and short term oncologic outcome were analysed. In addition, dose constraints for radiotherapy of the extremities were transferred from normofractionated to hypofractionated radiotherapy regimens. RESULTS: Feasibility was good with 17/18 patients completing treatment as planned. Wound healing complication rate was in the range of published data. Two patients developed local and distant recurrence, two patients isolated distant recurrences. No isolated local recurrences were observed. Keeping the constraints was possible in all cases without compromising the coverage of the target volume. CONCLUSIONS: Hypofractionated radiotherapy and surgery was well tolerated even in this specific patient population. With feasibility concerning early wound healing problems and adapted constraints, which allow for the treatment of most resectable extremity tumours, the concept warrants further evaluation in patients unfit for standard radiotherapy. |
format | Online Article Text |
id | pubmed-8647799 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Sciendo |
record_format | MEDLINE/PubMed |
spelling | pubmed-86477992021-12-20 Hypofractionated Preoperative Radiotherapy for High Risk Soft Tissue Sarcomas in a Geriatric Patient Population Potkrajcic, Vlatko Traub, Frank Hermes, Barbara Scharpf, Marcus Kolbenschlag, Jonas Zips, Daniel Paulsen, Frank Eckert, Franziska Radiol Oncol Research Article BACKGROUND: Standard therapy for localised, resectable high risk soft tissue sarcomas consists of wide excision and radiotherapy over several weeks. This treatment schedule is hardly feasible in geriatric and frail patients. In order not to withhold radiotherapy from these patients, hypofractionated radiotherapy with 25 Gy in 5 fractions was evaluated in a geriatric patient population. PATIENTS AND METHODS: A retrospective analysis was performed of 18 geriatric patients with resectable high risk soft tissue sarcomas of extremities and thoracic wall. Wound healing and short term oncologic outcome were analysed. In addition, dose constraints for radiotherapy of the extremities were transferred from normofractionated to hypofractionated radiotherapy regimens. RESULTS: Feasibility was good with 17/18 patients completing treatment as planned. Wound healing complication rate was in the range of published data. Two patients developed local and distant recurrence, two patients isolated distant recurrences. No isolated local recurrences were observed. Keeping the constraints was possible in all cases without compromising the coverage of the target volume. CONCLUSIONS: Hypofractionated radiotherapy and surgery was well tolerated even in this specific patient population. With feasibility concerning early wound healing problems and adapted constraints, which allow for the treatment of most resectable extremity tumours, the concept warrants further evaluation in patients unfit for standard radiotherapy. Sciendo 2021-11-19 /pmc/articles/PMC8647799/ /pubmed/34821137 http://dx.doi.org/10.2478/raon-2021-0038 Text en © 2021 Vlatko Potkrajcic, Frank Traub, Barbara Hermes, Marcus Scharpf, Jonas Kolbenschlag, Daniel Zips, Frank Paulsen, Franziska Eckert, published by Sciendo https://creativecommons.org/licenses/by-nc-nd/4.0/This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. |
spellingShingle | Research Article Potkrajcic, Vlatko Traub, Frank Hermes, Barbara Scharpf, Marcus Kolbenschlag, Jonas Zips, Daniel Paulsen, Frank Eckert, Franziska Hypofractionated Preoperative Radiotherapy for High Risk Soft Tissue Sarcomas in a Geriatric Patient Population |
title | Hypofractionated Preoperative Radiotherapy for High Risk Soft Tissue Sarcomas in a Geriatric Patient Population |
title_full | Hypofractionated Preoperative Radiotherapy for High Risk Soft Tissue Sarcomas in a Geriatric Patient Population |
title_fullStr | Hypofractionated Preoperative Radiotherapy for High Risk Soft Tissue Sarcomas in a Geriatric Patient Population |
title_full_unstemmed | Hypofractionated Preoperative Radiotherapy for High Risk Soft Tissue Sarcomas in a Geriatric Patient Population |
title_short | Hypofractionated Preoperative Radiotherapy for High Risk Soft Tissue Sarcomas in a Geriatric Patient Population |
title_sort | hypofractionated preoperative radiotherapy for high risk soft tissue sarcomas in a geriatric patient population |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8647799/ https://www.ncbi.nlm.nih.gov/pubmed/34821137 http://dx.doi.org/10.2478/raon-2021-0038 |
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