Human and rat skeletal muscle single-nuclei multi-omic integrative analyses nominate causal cell types, regulatory elements, and SNPs for complex traits

Skeletal muscle accounts for the largest proportion of human body mass, on average, and is a key tissue in complex diseases and mobility. It is composed of several different cell and muscle fiber types. Here, we optimize single-nucleus ATAC-seq (snATAC-seq) to map skeletal muscle cell–specific chrom...

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Detalles Bibliográficos
Autores principales: Orchard, Peter, Manickam, Nandini, Ventresca, Christa, Vadlamudi, Swarooparani, Varshney, Arushi, Rai, Vivek, Kaplan, Jeremy, Lalancette, Claudia, Mohlke, Karen L., Gallagher, Katherine, Burant, Charles F., Parker, Stephen C.J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8647829/
https://www.ncbi.nlm.nih.gov/pubmed/34815310
http://dx.doi.org/10.1101/gr.268482.120

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