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Eicosanoid production by Candida parapsilosis and other pathogenic yeasts

Eicosanoids are bioactive lipid mediators generated in almost all mammalian cells from the oxidation of arachidonic acid and other related twenty-carbon polyunsaturated fatty acids (PUFA). Eicosanoids regulate various physiological functions, including cellular homoeostasis and modulation of inflamm...

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Autores principales: Chakraborty, Tanmoy, Tóth, Renáta, Gácser, Attila
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8647850/
https://www.ncbi.nlm.nih.gov/pubmed/30558484
http://dx.doi.org/10.1080/21505594.2018.1559674
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author Chakraborty, Tanmoy
Tóth, Renáta
Gácser, Attila
author_facet Chakraborty, Tanmoy
Tóth, Renáta
Gácser, Attila
author_sort Chakraborty, Tanmoy
collection PubMed
description Eicosanoids are bioactive lipid mediators generated in almost all mammalian cells from the oxidation of arachidonic acid and other related twenty-carbon polyunsaturated fatty acids (PUFA). Eicosanoids regulate various physiological functions, including cellular homoeostasis and modulation of inflammatory responses in mammals. The mode of action of these lipid mediators depend on their binding to different G-protein coupled receptors. The three main enzymatic pathways associated with their production are the COX pathway, LOX pathway and cytochrome P450 pathway. Interestingly, investigations have also revealed that several human pathogenic fungi are capable of producing these bioactive lipid mediators; however, the exact biosynthetic pathways and their function in pathogenicity are not yet extensively characterized. The aim of the current review is to summarize the recent discoveries pertaining to eicosanoid production by human pathogenic yeasts with a special focus on the opportunistic human fungal pathogen Candida parapsilosis.
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spelling pubmed-86478502021-12-07 Eicosanoid production by Candida parapsilosis and other pathogenic yeasts Chakraborty, Tanmoy Tóth, Renáta Gácser, Attila Virulence Special issue on Fungal Infections Eicosanoids are bioactive lipid mediators generated in almost all mammalian cells from the oxidation of arachidonic acid and other related twenty-carbon polyunsaturated fatty acids (PUFA). Eicosanoids regulate various physiological functions, including cellular homoeostasis and modulation of inflammatory responses in mammals. The mode of action of these lipid mediators depend on their binding to different G-protein coupled receptors. The three main enzymatic pathways associated with their production are the COX pathway, LOX pathway and cytochrome P450 pathway. Interestingly, investigations have also revealed that several human pathogenic fungi are capable of producing these bioactive lipid mediators; however, the exact biosynthetic pathways and their function in pathogenicity are not yet extensively characterized. The aim of the current review is to summarize the recent discoveries pertaining to eicosanoid production by human pathogenic yeasts with a special focus on the opportunistic human fungal pathogen Candida parapsilosis. Taylor & Francis 2019-01-07 /pmc/articles/PMC8647850/ /pubmed/30558484 http://dx.doi.org/10.1080/21505594.2018.1559674 Text en © 2019 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Special issue on Fungal Infections
Chakraborty, Tanmoy
Tóth, Renáta
Gácser, Attila
Eicosanoid production by Candida parapsilosis and other pathogenic yeasts
title Eicosanoid production by Candida parapsilosis and other pathogenic yeasts
title_full Eicosanoid production by Candida parapsilosis and other pathogenic yeasts
title_fullStr Eicosanoid production by Candida parapsilosis and other pathogenic yeasts
title_full_unstemmed Eicosanoid production by Candida parapsilosis and other pathogenic yeasts
title_short Eicosanoid production by Candida parapsilosis and other pathogenic yeasts
title_sort eicosanoid production by candida parapsilosis and other pathogenic yeasts
topic Special issue on Fungal Infections
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8647850/
https://www.ncbi.nlm.nih.gov/pubmed/30558484
http://dx.doi.org/10.1080/21505594.2018.1559674
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