Myocarditis and COVID-19 mRNA vaccines: a mechanistic hypothesis involving dsRNA

While tolerance to COVID-19 vaccination is considered satisfactory, a phenomenon of myocarditis, although rare, is becoming a safety concern in mRNA COVID-19 vaccination. The presence of low residual levels of double-strand RNA (dsRNA) has been reported in mRNA COVID-19 vaccine preparations. dsRNA i...

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Detalles Bibliográficos
Autores principales: Milano, Gerard, Gal, Jocelyn, Creisson, Anne, Chamorey, Emmanuel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Future Medicine Ltd 2021
Materias:
Special Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8647997/
https://www.ncbi.nlm.nih.gov/pubmed/34887937
http://dx.doi.org/10.2217/fvl-2021-0280
Descripción
Sumario:While tolerance to COVID-19 vaccination is considered satisfactory, a phenomenon of myocarditis, although rare, is becoming a safety concern in mRNA COVID-19 vaccination. The presence of low residual levels of double-strand RNA (dsRNA) has been reported in mRNA COVID-19 vaccine preparations. dsRNA is a known inducer of immune-inflammatory reactions. dsRNA present in vaccine nanoparticles may be suspected to be at the origin of the still unexplained cases of myocarditis.

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