Myocarditis and COVID-19 mRNA vaccines: a mechanistic hypothesis involving dsRNA

While tolerance to COVID-19 vaccination is considered satisfactory, a phenomenon of myocarditis, although rare, is becoming a safety concern in mRNA COVID-19 vaccination. The presence of low residual levels of double-strand RNA (dsRNA) has been reported in mRNA COVID-19 vaccine preparations. dsRNA i...

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Detalles Bibliográficos
Autores principales: Milano, Gerard, Gal, Jocelyn, Creisson, Anne, Chamorey, Emmanuel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Future Medicine Ltd 2021
Materias:
Special Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8647997/
https://www.ncbi.nlm.nih.gov/pubmed/34887937
http://dx.doi.org/10.2217/fvl-2021-0280
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author Milano, Gerard
Gal, Jocelyn
Creisson, Anne
Chamorey, Emmanuel
author_facet Milano, Gerard
Gal, Jocelyn
Creisson, Anne
Chamorey, Emmanuel
author_sort Milano, Gerard
collection PubMed
description While tolerance to COVID-19 vaccination is considered satisfactory, a phenomenon of myocarditis, although rare, is becoming a safety concern in mRNA COVID-19 vaccination. The presence of low residual levels of double-strand RNA (dsRNA) has been reported in mRNA COVID-19 vaccine preparations. dsRNA is a known inducer of immune-inflammatory reactions. dsRNA present in vaccine nanoparticles may be suspected to be at the origin of the still unexplained cases of myocarditis.
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spelling pubmed-86479972021-12-07 Myocarditis and COVID-19 mRNA vaccines: a mechanistic hypothesis involving dsRNA Milano, Gerard Gal, Jocelyn Creisson, Anne Chamorey, Emmanuel Future Virol Special Report While tolerance to COVID-19 vaccination is considered satisfactory, a phenomenon of myocarditis, although rare, is becoming a safety concern in mRNA COVID-19 vaccination. The presence of low residual levels of double-strand RNA (dsRNA) has been reported in mRNA COVID-19 vaccine preparations. dsRNA is a known inducer of immune-inflammatory reactions. dsRNA present in vaccine nanoparticles may be suspected to be at the origin of the still unexplained cases of myocarditis. Future Medicine Ltd 2021-12-06 2021-11 /pmc/articles/PMC8647997/ /pubmed/34887937 http://dx.doi.org/10.2217/fvl-2021-0280 Text en © 2021 Future Medicine Ltd https://creativecommons.org/licenses/by/4.0/This work is licensed under the Creative Commons Attribution 4.0 License (https://creativecommons.org/licenses/by/4.0/)
spellingShingle Special Report
Milano, Gerard
Gal, Jocelyn
Creisson, Anne
Chamorey, Emmanuel
Myocarditis and COVID-19 mRNA vaccines: a mechanistic hypothesis involving dsRNA
title Myocarditis and COVID-19 mRNA vaccines: a mechanistic hypothesis involving dsRNA
title_full Myocarditis and COVID-19 mRNA vaccines: a mechanistic hypothesis involving dsRNA
title_fullStr Myocarditis and COVID-19 mRNA vaccines: a mechanistic hypothesis involving dsRNA
title_full_unstemmed Myocarditis and COVID-19 mRNA vaccines: a mechanistic hypothesis involving dsRNA
title_short Myocarditis and COVID-19 mRNA vaccines: a mechanistic hypothesis involving dsRNA
title_sort myocarditis and covid-19 mrna vaccines: a mechanistic hypothesis involving dsrna
topic Special Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8647997/
https://www.ncbi.nlm.nih.gov/pubmed/34887937
http://dx.doi.org/10.2217/fvl-2021-0280
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AT chamoreyemmanuel myocarditisandcovid19mrnavaccinesamechanistichypothesisinvolvingdsrna

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