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Britanin relieves ferroptosis-mediated myocardial ischaemia/reperfusion damage by upregulating GPX4 through activation of AMPK/GSK3β/Nrf2 signalling

CONTEXT: Ferroptosis was described as an important contributor to the myocardial ischaemia/reperfusion (MIR) injury, and britanin (Bri) was reported to exert antitumor and anti-inflammatory activities. OBJECTIVE: Our study explores the effect and mechanism of Bri on MIR damage. MATERIALS AND METHODS...

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Detalles Bibliográficos
Autores principales:	Lu, Haoyang, Xiao, Hui, Dai, Manyu, Xue, Yangcheng, Zhao, Ren
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taylor & Francis 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8648013/ https://www.ncbi.nlm.nih.gov/pubmed/34860639 http://dx.doi.org/10.1080/13880209.2021.2007269

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