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Host-cell interactions in HBV infection and pathogenesis: the emerging role of m6A modification

Hepatitis B virus (HBV) is a DNA virus with a complex life cycle that includes a reverse transcription step. HBV is poorly sensed by the immune system and frequently establishes persistent infection that can cause chronic infection, the leading cause of liver cancer and cirrhosis worldwide. Recent m...

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Autores principales: Kostyusheva, Anastasiya, Brezgin, Sergey, Glebe, Dieter, Kostyushev, Dmitry, Chulanov, Vladimir
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8648018/
https://www.ncbi.nlm.nih.gov/pubmed/34767497
http://dx.doi.org/10.1080/22221751.2021.2006580
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author Kostyusheva, Anastasiya
Brezgin, Sergey
Glebe, Dieter
Kostyushev, Dmitry
Chulanov, Vladimir
author_facet Kostyusheva, Anastasiya
Brezgin, Sergey
Glebe, Dieter
Kostyushev, Dmitry
Chulanov, Vladimir
author_sort Kostyusheva, Anastasiya
collection PubMed
description Hepatitis B virus (HBV) is a DNA virus with a complex life cycle that includes a reverse transcription step. HBV is poorly sensed by the immune system and frequently establishes persistent infection that can cause chronic infection, the leading cause of liver cancer and cirrhosis worldwide. Recent mounting evidence has indicated the growing importance of RNA methylation (m6A modification) in viral replication, immune escape, and carcinogenesis. The value of m6A RNA modification for the prediction and clinical management of chronic HBV infection remains to be assessed. However, a number of studies indicate the important role of m6A-marked transcripts and factors of m6A machinery in managing HBV-related pathologies. In this review, we discuss the fundamental and potential clinical impact of m6A modifications on HBV infection and pathogenesis, as well as highlight the important molecular techniques and tools that can be used for studying RNA m6A methylome.
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spelling pubmed-86480182021-12-07 Host-cell interactions in HBV infection and pathogenesis: the emerging role of m6A modification Kostyusheva, Anastasiya Brezgin, Sergey Glebe, Dieter Kostyushev, Dmitry Chulanov, Vladimir Emerg Microbes Infect Hepatitis - Updates from the Classical Emerging Infection Hepatitis B virus (HBV) is a DNA virus with a complex life cycle that includes a reverse transcription step. HBV is poorly sensed by the immune system and frequently establishes persistent infection that can cause chronic infection, the leading cause of liver cancer and cirrhosis worldwide. Recent mounting evidence has indicated the growing importance of RNA methylation (m6A modification) in viral replication, immune escape, and carcinogenesis. The value of m6A RNA modification for the prediction and clinical management of chronic HBV infection remains to be assessed. However, a number of studies indicate the important role of m6A-marked transcripts and factors of m6A machinery in managing HBV-related pathologies. In this review, we discuss the fundamental and potential clinical impact of m6A modifications on HBV infection and pathogenesis, as well as highlight the important molecular techniques and tools that can be used for studying RNA m6A methylome. Taylor & Francis 2021-12-01 /pmc/articles/PMC8648018/ /pubmed/34767497 http://dx.doi.org/10.1080/22221751.2021.2006580 Text en © 2021 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Hepatitis - Updates from the Classical Emerging Infection
Kostyusheva, Anastasiya
Brezgin, Sergey
Glebe, Dieter
Kostyushev, Dmitry
Chulanov, Vladimir
Host-cell interactions in HBV infection and pathogenesis: the emerging role of m6A modification
title Host-cell interactions in HBV infection and pathogenesis: the emerging role of m6A modification
title_full Host-cell interactions in HBV infection and pathogenesis: the emerging role of m6A modification
title_fullStr Host-cell interactions in HBV infection and pathogenesis: the emerging role of m6A modification
title_full_unstemmed Host-cell interactions in HBV infection and pathogenesis: the emerging role of m6A modification
title_short Host-cell interactions in HBV infection and pathogenesis: the emerging role of m6A modification
title_sort host-cell interactions in hbv infection and pathogenesis: the emerging role of m6a modification
topic Hepatitis - Updates from the Classical Emerging Infection
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8648018/
https://www.ncbi.nlm.nih.gov/pubmed/34767497
http://dx.doi.org/10.1080/22221751.2021.2006580
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