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Synthesis and structure-activity relationship study of new biaryl amide derivatives and their inhibitory effects against hepatitis C virus

A series of novel biaryl amide derivatives were synthesized and evaluated for anti-HCV virus activity. Some significant SARs were uncovered. The intensive structural modifications led to fifteen novel compounds with more potent inhibitory activity compared to the hit compounds IMB 26 and IMB1f. Amon...

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Detalles Bibliográficos
Autores principales:	Liu, Yonghua, Li, Jianrui, Gu, Yuxi, Ma, Ling, Cen, Shan, Peng, Zonggen, Hu, Laixing
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Published by Elsevier Masson SAS. 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8648050/ https://www.ncbi.nlm.nih.gov/pubmed/34883293 http://dx.doi.org/10.1016/j.ejmech.2021.114033

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