SARS-CoV-2 spike binding to ACE2 is stronger and longer ranged due to glycan interaction

Highly detailed steered molecular dynamics simulations are performed on differently glycosylated receptor binding domains of the severe acute respiratory syndrome coronavirus-2 spike protein. The binding strength and the binding range increase with glycosylation. The interaction energy rises very qu...

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Detalles Bibliográficos
Autores principales: Huang, Yihan, Harris, Bradley S., Minami, Shiaki A., Jung, Seongwon, Shah, Priya S., Nandi, Somen, McDonald, Karen A., Faller, Roland
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Biophysical Society 2022
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8648368/
https://www.ncbi.nlm.nih.gov/pubmed/34883069
http://dx.doi.org/10.1016/j.bpj.2021.12.002

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