Pharmacokinetic Characterisation and Comparison of Bioavailability of Intranasal Fentanyl, Transmucosal, and Intravenous Administration through a Three-Way Crossover Study in 24 Healthy Volunteers

BACKGROUND: For more than 60 years, the synthetic opioid fentanyl has been widely used in anaesthesia and analgesia. While the intravenous formulation is primarily used for general anaesthesia and intensive care settings, the drug's high lipophilic properties also allow various noninvasive rout...

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Detalles Bibliográficos
Autores principales: Nardi-Hiebl, S., Ndieyira, J. W., Al Enzi, Y., Al Akkad, W., Koch, T., Geldner, G., Reyher, C., Eberhart, L. H. J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8648480/
https://www.ncbi.nlm.nih.gov/pubmed/34880961
http://dx.doi.org/10.1155/2021/2887773

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