Cargando…

PrP(C) as a Transducer of Physiological and Pathological Signals

After the discovery of prion phenomenon, the physiological role of the cellular prion protein (PrP(C)) remained elusive. In the past decades, molecular and cellular analysis has shed some light regarding interactions and functions of PrP(C) in health and disease. PrP(C), which is located mainly at t...

Descripción completa

Detalles Bibliográficos
Autores principales:	Panes, Jessica D., Saavedra, Paulina, Pineda, Benjamin, Escobar, Kathleen, Cuevas, Magdalena E., Moraga-Cid, Gustavo, Fuentealba, Jorge, Rivas, Coralia I., Rezaei, Human, Muñoz-Montesino, Carola
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8648500/ https://www.ncbi.nlm.nih.gov/pubmed/34880726 http://dx.doi.org/10.3389/fnmol.2021.762918

Ejemplares similares

Therapeutic Use of Vitamin C in Cancer: Physiological Considerations
por: Roa, Francisco J., et al.
Publicado: (2020)

The mechanism of monomer transfer between two structurally distinct PrP oligomers
por: Armiento, Aurora, et al.
Publicado: (2017)

Prion potentiation after life-long dormancy in mice devoid of PrP
por: Martin, Davy, et al.
Publicado: (2021)

Prion protein (PrP) gene-knockout cell lines: insight into functions of the PrP
por: Sakudo, Akikazu, et al.
Publicado: (2015)

PK-sensitive PrP(Sc) Is Infectious and Shares Basic Structural Features with PK-resistant PrP(Sc)
por: Sajnani, Gustavo, et al.
Publicado: (2012)

Divergent prion strain evolution driven by PrP(C) expression level in transgenic mice
por: Le Dur, Annick, et al.
Publicado: (2017)

The Structure of PrP(Sc) Prions
por: Wille, Holger, et al.
Publicado: (2018)

PrP Expression, PrP(Sc) Accumulation and Innervation of Splenic Compartments in Sheep Experimentally Infected with Scrapie
por: Sørby, Randi, et al.
Publicado: (2009)

Anti-Prion Drug mPPIg5 Inhibits PrP(C) Conversion to PrP(Sc)
por: McCarthy, James M., et al.
Publicado: (2013)

Infectivity-associated PrP(Sc) and disease duration-associated PrP(Sc) of mouse BSE prions
por: Miyazawa, Kohtaro, et al.
Publicado: (2015)

The native state of prion protein (PrP) directly inhibits formation of PrP-amyloid fibrils in vitro
por: Honda, Ryo P., et al.
Publicado: (2017)

Predicting the consequences of selecting on PrP genotypes on PrP frequencies, performance and inbreeding in commercial meat sheep populations
por: Man, Wing-Young N, et al.
Publicado: (2007)

Small Protease Sensitive Oligomers of PrP(Sc) in Distinct Human Prions Determine Conversion Rate of PrP(C)
por: Kim, Chae, et al.
Publicado: (2012)

Glimepiride Reduces the Expression of PrP(C), Prevents PrP(Sc) Formation and Protects against Prion Mediated Neurotoxicity
por: Bate, Clive, et al.
Publicado: (2009)

A Camelid Anti-PrP Antibody Abrogates PrP(Sc) Replication in Prion-Permissive Neuroblastoma Cell Lines
por: Jones, Daryl Rhys, et al.
Publicado: (2010)

Identifying critical sites of PrP(c)-PrP(Sc) interaction in prion-infected cells by dominant-negative inhibition
por: Taguchi, Yuzuru, et al.
Publicado: (2013)

PrP aggregation can be seeded by pre-formed recombinant PrP amyloid fibrils without the replication of infectious prions
por: Barron, Rona M., et al.
Publicado: (2016)

Recombinant PrP(Sc) shares structural features with brain-derived PrP(Sc): Insights from limited proteolysis
por: Sevillano, Alejandro M., et al.
Publicado: (2018)

Exploration of the Main Sites for the Transformation of Normal Prion Protein (PrP(C)) into Pathogenic Prion Protein (PrP(sc))
por: Liu, Xi-Lin, et al.
Publicado: (2017)

Na(+)/K(+)-ATPase Is Present in Scrapie-Associated Fibrils, Modulates PrP Misfolding In Vitro and Links PrP Function and Dysfunction
por: Graham, James F., et al.
Publicado: (2011)

Nanopore Analysis of Wild-Type and Mutant Prion Protein (PrP(C)): Single Molecule Discrimination and PrP(C) Kinetics
por: Jetha, Nahid N., et al.
Publicado: (2013)

Heterogeneity of Abnormal Prion Protein (PrP(Sc)) in Murine Scrapie Prions Determined by PrP(Sc)-Specific Monoclonal Antibodies
por: USHIKI-KAKU, Yuko, et al.
Publicado: (2013)

The ZIP5 Ectodomain Co-Localizes with PrP and May Acquire a PrP-Like Fold That Assembles into a Dimer
por: Pocanschi, Cosmin L., et al.
Publicado: (2013)

PrP(ST), a Soluble, Protease Resistant and Truncated PrP Form Features in the Pathogenesis of a Genetic Prion Disease
por: Friedman-Levi, Yael, et al.
Publicado: (2013)

Low fraction of the 222K PrP variant in the protease-resistant moiety of PrP(res) in heterozygous scrapie positive goats
por: Mazza, Maria, et al.
Publicado: (2017)

Enhancement of binding avidity by bivalent binding enables PrP(Sc)-specific detection by anti-PrP monoclonal antibody 132
por: Suzuki, Akio, et al.
Publicado: (2019)

Emergence of two prion subtypes in ovine PrP transgenic mice infected with human MM2-cortical Creutzfeldt-Jakob disease prions
por: Chapuis, Jérôme, et al.
Publicado: (2016)

Species and Strain Glycosylation Patterns of PrP(Sc)
por: Xanthopoulos, Konstantinos, et al.
Publicado: (2009)

Regulation of PrP(C) signaling and processing by dimerization
por: Roucou, Xavier
Publicado: (2014)

PrP(C) from stem cells to cancer
por: Martin-Lannerée, Séverine, et al.
Publicado: (2014)

PrP charge structure encodes interdomain interactions
por: Martínez, Javier, et al.
Publicado: (2015)

Mammalian prion propagation in PrP transgenic Drosophila
por: Thackray, Alana M, et al.
Publicado: (2018)

Sulfated Dextrans Enhance In Vitro Amplification of Bovine Spongiform Encephalopathy PrP(Sc) and Enable Ultrasensitive Detection of Bovine PrP(Sc)
por: Murayama, Yuichi, et al.
Publicado: (2010)

Correction: PrP(ST), a Soluble, Protease Resistant and Truncated PrP Form Features in the Pathogenesis of a Genetic Prion Disease
por: Friedman-Levi, Yael, et al.
Publicado: (2015)

Quaternary Structure Changes for PrP(Sc) Predate PrP(C) Downregulation and Neuronal Death During Progression of Experimental Scrapie Disease
por: Eskandari-Sedighi, Ghazaleh, et al.
Publicado: (2020)

Inhibition of the Glycine Receptor alpha 3 Function by Colchicine
por: Muñoz-Montesino, Carola, et al.
Publicado: (2020)

Elephant Black Garlic’s Beneficial Properties for Hippocampal Neuronal Network, Chemical Characterization and Biological Evaluation
por: Gavilán, Javiera, et al.
Publicado: (2023)

Prion Protein (PrP) Knock-Out Mice Show Altered Iron Metabolism: A Functional Role for PrP in Iron Uptake and Transport
por: Singh, Ajay, et al.
Publicado: (2009)

PMCA-replicated PrP(D) in urine of vCJD patients maintains infectivity and strain characteristics of brain PrP(D): Transmission study
por: Cali, Ignazio, et al.
Publicado: (2019)

Canine D(163)-PrP polymorphic variant does not provide complete protection against prion infection in small ruminant PrP context
por: Marín-Moreno, Alba, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_9t5a1tocss0ov2adlq9jk62eec