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Hypoalbuminemia is related to endothelial dysfunction resulting from oxidative stress in parturients with preeclampsia

Serum albumin levels are inversely related with oxidative stress, but positively related with endothelial function, in pregnant women. However, it is unclear whether hypoalbuminemia in pregnant women with preeclampsia (PE) increases the production of oxygen-derived free radicals and impacts endothel...

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Autores principales: Saitou, Takuya, Watanabe, Kazushi, Kinoshita, Hiroyuki, Iwasaki, Ai, Owaki, Yuki, Matsushita, Hiroshi, Wakatsuki, Akihiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nagoya University 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8648536/
https://www.ncbi.nlm.nih.gov/pubmed/34916718
http://dx.doi.org/10.18999/nagjms.83.4.741
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author Saitou, Takuya
Watanabe, Kazushi
Kinoshita, Hiroyuki
Iwasaki, Ai
Owaki, Yuki
Matsushita, Hiroshi
Wakatsuki, Akihiko
author_facet Saitou, Takuya
Watanabe, Kazushi
Kinoshita, Hiroyuki
Iwasaki, Ai
Owaki, Yuki
Matsushita, Hiroshi
Wakatsuki, Akihiko
author_sort Saitou, Takuya
collection PubMed
description Serum albumin levels are inversely related with oxidative stress, but positively related with endothelial function, in pregnant women. However, it is unclear whether hypoalbuminemia in pregnant women with preeclampsia (PE) increases the production of oxygen-derived free radicals and impacts endothelial function. The present study aimed to assess the relationship between serum albumin, oxidative stress, and endothelial dysfunction in pregnant women with PE. A total of 75 women with control pregnancy (Control group, n = 30), PE (PE group, n = 24), or gestational hypertension (GH) (GH group, n = 21) were enrolled. We assessed serum albumin levels, diacron-reactive oxygen metabolites (d-ROMs) as an oxygen-derived free radical marker, and flow-mediated dilation (FMD) as a readout for vascular endothelial function during the gestational period and at one month after delivery. During the gestational period, FMD was lower, but d-ROM levels were higher, in the PE and GH groups compared with the Control group. Serum albumin levels were lower in the PE group compared with the Control and GH groups. d-ROM levels were inversely correlated with serum albumin levels (r = –0.54, p < 0.05) and FMD (r = –0.56, p < 0.05) in the PE group, and negatively correlated with FMD, but not serum albumin levels, in the GH group. Serum levels of d-ROMs and albumin, as well as FMD, were similar between groups after delivery. Our findings suggest that reduced serum albumin levels enhance the production of oxygen-derived free radicals, resulting in impaired maternal vascular endothelial function in parturients with PE.
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spelling pubmed-86485362021-12-15 Hypoalbuminemia is related to endothelial dysfunction resulting from oxidative stress in parturients with preeclampsia Saitou, Takuya Watanabe, Kazushi Kinoshita, Hiroyuki Iwasaki, Ai Owaki, Yuki Matsushita, Hiroshi Wakatsuki, Akihiko Nagoya J Med Sci Original Paper Serum albumin levels are inversely related with oxidative stress, but positively related with endothelial function, in pregnant women. However, it is unclear whether hypoalbuminemia in pregnant women with preeclampsia (PE) increases the production of oxygen-derived free radicals and impacts endothelial function. The present study aimed to assess the relationship between serum albumin, oxidative stress, and endothelial dysfunction in pregnant women with PE. A total of 75 women with control pregnancy (Control group, n = 30), PE (PE group, n = 24), or gestational hypertension (GH) (GH group, n = 21) were enrolled. We assessed serum albumin levels, diacron-reactive oxygen metabolites (d-ROMs) as an oxygen-derived free radical marker, and flow-mediated dilation (FMD) as a readout for vascular endothelial function during the gestational period and at one month after delivery. During the gestational period, FMD was lower, but d-ROM levels were higher, in the PE and GH groups compared with the Control group. Serum albumin levels were lower in the PE group compared with the Control and GH groups. d-ROM levels were inversely correlated with serum albumin levels (r = –0.54, p < 0.05) and FMD (r = –0.56, p < 0.05) in the PE group, and negatively correlated with FMD, but not serum albumin levels, in the GH group. Serum levels of d-ROMs and albumin, as well as FMD, were similar between groups after delivery. Our findings suggest that reduced serum albumin levels enhance the production of oxygen-derived free radicals, resulting in impaired maternal vascular endothelial function in parturients with PE. Nagoya University 2021-11 /pmc/articles/PMC8648536/ /pubmed/34916718 http://dx.doi.org/10.18999/nagjms.83.4.741 Text en https://creativecommons.org/licenses/by-nc-nd/4.0/This is an Open Access article distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) ).
spellingShingle Original Paper
Saitou, Takuya
Watanabe, Kazushi
Kinoshita, Hiroyuki
Iwasaki, Ai
Owaki, Yuki
Matsushita, Hiroshi
Wakatsuki, Akihiko
Hypoalbuminemia is related to endothelial dysfunction resulting from oxidative stress in parturients with preeclampsia
title Hypoalbuminemia is related to endothelial dysfunction resulting from oxidative stress in parturients with preeclampsia
title_full Hypoalbuminemia is related to endothelial dysfunction resulting from oxidative stress in parturients with preeclampsia
title_fullStr Hypoalbuminemia is related to endothelial dysfunction resulting from oxidative stress in parturients with preeclampsia
title_full_unstemmed Hypoalbuminemia is related to endothelial dysfunction resulting from oxidative stress in parturients with preeclampsia
title_short Hypoalbuminemia is related to endothelial dysfunction resulting from oxidative stress in parturients with preeclampsia
title_sort hypoalbuminemia is related to endothelial dysfunction resulting from oxidative stress in parturients with preeclampsia
topic Original Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8648536/
https://www.ncbi.nlm.nih.gov/pubmed/34916718
http://dx.doi.org/10.18999/nagjms.83.4.741
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