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Periprocedural complications and one-year outcomes after catheter ablation for treatment of atrial fibrillation in elderly patients: a nationwide Danish cohort study

OBJECTIVES: To investigate complications within 30-days following first-time ablation for atrial fibrillation (AF), including a composite of cardiac tamponade, hematoma requiring intervention, stroke or death, in patients ≥ 75 years of age, compared to patients aged 65−74 years. In addition, one-yea...

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Autores principales: Nielsen, Jesper, Kragholm, Kristian Hay, Christensen, Sofie Brix, Johannessen, Arne, Torp-Pedersen, Christian, Kristiansen, Steen Buus, Jacobsen, Peter Karl, Hansen, Peter Steen, Djurhus, Mogens Stig, Polcwiartek, Christoffer, Søgaard, Peter, Thøgersen, Anna Margrethe, Gang, Uffe Jakob Ortved, Jørgensen, Ole Dan, Lindgren, Filip Lyng, Riahi, Sam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Science Press 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8648543/
https://www.ncbi.nlm.nih.gov/pubmed/34908927
http://dx.doi.org/10.11909/j.issn.1671-5411.2021.11.005
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author Nielsen, Jesper
Kragholm, Kristian Hay
Christensen, Sofie Brix
Johannessen, Arne
Torp-Pedersen, Christian
Kristiansen, Steen Buus
Jacobsen, Peter Karl
Hansen, Peter Steen
Djurhus, Mogens Stig
Polcwiartek, Christoffer
Søgaard, Peter
Thøgersen, Anna Margrethe
Gang, Uffe Jakob Ortved
Jørgensen, Ole Dan
Lindgren, Filip Lyng
Riahi, Sam
author_facet Nielsen, Jesper
Kragholm, Kristian Hay
Christensen, Sofie Brix
Johannessen, Arne
Torp-Pedersen, Christian
Kristiansen, Steen Buus
Jacobsen, Peter Karl
Hansen, Peter Steen
Djurhus, Mogens Stig
Polcwiartek, Christoffer
Søgaard, Peter
Thøgersen, Anna Margrethe
Gang, Uffe Jakob Ortved
Jørgensen, Ole Dan
Lindgren, Filip Lyng
Riahi, Sam
author_sort Nielsen, Jesper
collection PubMed
description OBJECTIVES: To investigate complications within 30-days following first-time ablation for atrial fibrillation (AF), including a composite of cardiac tamponade, hematoma requiring intervention, stroke or death, in patients ≥ 75 years of age, compared to patients aged 65−74 years. In addition, one-year all-cause mortality and AF relapse were compared. METHODS & RESULTS: All patients receiving their first catheter ablation for AF between 2012 and 2016 were identified using Danish nationwide registries. Patients aged 65−74 years served as the reference group for patients ≥ 75 years. Relapse of AF within one year was defined as cardioversion following a three-month blanking period, re-ablation or confirmed relapse within follow-up. The composite complication outcome did not differ between the two age groups, with 39/1554 (2.8%) in patients 65−74 years of age, versus 5/199 (2.5%) in older patients (adjusted HR = 0.94), 95% CI: 0.37−2.39, P = 0.896). Patients ≥ 75 years or older had no increased hazard of death within 30 days after the procedure, with an incidence of 3/1554 (0.2%) in younger patients and 2/199 (1.0%) in patients ≥ 75 years of age (adjusted HR = 4.71, 95% CI: 0.78−28.40, P = 0.091). There was no difference in relapse of AF after one year between age groups (≥ 75 years adjusted HR = 1.00, 95% CI: 0.78-1.26, P = 0.969). CONCLUSION: In patients ≥ 75 years of age selected for catheter ablation for AF, the incidence of periprocedural complications, as well as one-year freedom from AF showed no statistical difference, when compared to patients 65−74 years of age.
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spelling pubmed-86485432021-12-13 Periprocedural complications and one-year outcomes after catheter ablation for treatment of atrial fibrillation in elderly patients: a nationwide Danish cohort study Nielsen, Jesper Kragholm, Kristian Hay Christensen, Sofie Brix Johannessen, Arne Torp-Pedersen, Christian Kristiansen, Steen Buus Jacobsen, Peter Karl Hansen, Peter Steen Djurhus, Mogens Stig Polcwiartek, Christoffer Søgaard, Peter Thøgersen, Anna Margrethe Gang, Uffe Jakob Ortved Jørgensen, Ole Dan Lindgren, Filip Lyng Riahi, Sam J Geriatr Cardiol Research Article OBJECTIVES: To investigate complications within 30-days following first-time ablation for atrial fibrillation (AF), including a composite of cardiac tamponade, hematoma requiring intervention, stroke or death, in patients ≥ 75 years of age, compared to patients aged 65−74 years. In addition, one-year all-cause mortality and AF relapse were compared. METHODS & RESULTS: All patients receiving their first catheter ablation for AF between 2012 and 2016 were identified using Danish nationwide registries. Patients aged 65−74 years served as the reference group for patients ≥ 75 years. Relapse of AF within one year was defined as cardioversion following a three-month blanking period, re-ablation or confirmed relapse within follow-up. The composite complication outcome did not differ between the two age groups, with 39/1554 (2.8%) in patients 65−74 years of age, versus 5/199 (2.5%) in older patients (adjusted HR = 0.94), 95% CI: 0.37−2.39, P = 0.896). Patients ≥ 75 years or older had no increased hazard of death within 30 days after the procedure, with an incidence of 3/1554 (0.2%) in younger patients and 2/199 (1.0%) in patients ≥ 75 years of age (adjusted HR = 4.71, 95% CI: 0.78−28.40, P = 0.091). There was no difference in relapse of AF after one year between age groups (≥ 75 years adjusted HR = 1.00, 95% CI: 0.78-1.26, P = 0.969). CONCLUSION: In patients ≥ 75 years of age selected for catheter ablation for AF, the incidence of periprocedural complications, as well as one-year freedom from AF showed no statistical difference, when compared to patients 65−74 years of age. Science Press 2021-11-28 /pmc/articles/PMC8648543/ /pubmed/34908927 http://dx.doi.org/10.11909/j.issn.1671-5411.2021.11.005 Text en Copyright and License information: Journal of Geriatric Cardiology 2021 https://creativecommons.org/licenses/by-nc-sa/4.0/This work is licensed under a Creative Commons Attribution-NonCommercial-Share Alike 4.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/4.0/ (https://creativecommons.org/licenses/by-nc-sa/4.0/)
spellingShingle Research Article
Nielsen, Jesper
Kragholm, Kristian Hay
Christensen, Sofie Brix
Johannessen, Arne
Torp-Pedersen, Christian
Kristiansen, Steen Buus
Jacobsen, Peter Karl
Hansen, Peter Steen
Djurhus, Mogens Stig
Polcwiartek, Christoffer
Søgaard, Peter
Thøgersen, Anna Margrethe
Gang, Uffe Jakob Ortved
Jørgensen, Ole Dan
Lindgren, Filip Lyng
Riahi, Sam
Periprocedural complications and one-year outcomes after catheter ablation for treatment of atrial fibrillation in elderly patients: a nationwide Danish cohort study
title Periprocedural complications and one-year outcomes after catheter ablation for treatment of atrial fibrillation in elderly patients: a nationwide Danish cohort study
title_full Periprocedural complications and one-year outcomes after catheter ablation for treatment of atrial fibrillation in elderly patients: a nationwide Danish cohort study
title_fullStr Periprocedural complications and one-year outcomes after catheter ablation for treatment of atrial fibrillation in elderly patients: a nationwide Danish cohort study
title_full_unstemmed Periprocedural complications and one-year outcomes after catheter ablation for treatment of atrial fibrillation in elderly patients: a nationwide Danish cohort study
title_short Periprocedural complications and one-year outcomes after catheter ablation for treatment of atrial fibrillation in elderly patients: a nationwide Danish cohort study
title_sort periprocedural complications and one-year outcomes after catheter ablation for treatment of atrial fibrillation in elderly patients: a nationwide danish cohort study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8648543/
https://www.ncbi.nlm.nih.gov/pubmed/34908927
http://dx.doi.org/10.11909/j.issn.1671-5411.2021.11.005
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