Cargando…
Postmortem findings in COVID-19 fatalities: A systematic review of current evidence
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for the ongoing pandemic of coronavirus disease 2019 (COVID-19). Almost 17 months after the first COVID-19 case was reported, the exact pathogenesis of the virus is still open to interpretation. Postmortem studies have b...
Autores principales: | , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier B.V.
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8648585/ https://www.ncbi.nlm.nih.gov/pubmed/34952452 http://dx.doi.org/10.1016/j.legalmed.2021.102001 |
_version_ | 1784610838688038912 |
---|---|
author | Menezes, Ritesh G. Rizwan, Tehlil Saad Ali, Syed Hassan, Wardah Khetpal, Akash Aqil, Mohammad Madadin, Mohammed Jamal Siddiqi, Tariq Shariq Usman, Muhammad |
author_facet | Menezes, Ritesh G. Rizwan, Tehlil Saad Ali, Syed Hassan, Wardah Khetpal, Akash Aqil, Mohammad Madadin, Mohammed Jamal Siddiqi, Tariq Shariq Usman, Muhammad |
author_sort | Menezes, Ritesh G. |
collection | PubMed |
description | The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for the ongoing pandemic of coronavirus disease 2019 (COVID-19). Almost 17 months after the first COVID-19 case was reported, the exact pathogenesis of the virus is still open to interpretation. Postmortem studies have been relatively scarce due to the high infectivity rate of the virus. We systematically reviewed the literature available for studies that reported gross, histological, microscopic, and immunohistochemical findings in COVID-19 fatalities with the aim of reporting any recurrent findings among different demographics. PubMed and Scopus were searched up till the second of May 2021 and 46 studies with a total of 793 patients were shortlisted after the application of inclusion and exclusion criteria. The selected studies reported gross, histological, microscopic, and immunohistochemical autopsy findings in the lungs, heart, liver, gallbladder, bowels, kidney, spleen, bone marrow, lymph nodes, CNS, pancreas, endocrine/exocrine glands, and a few other miscellaneous locations. The SARS-CoV-2 virus was detected in multiple organs and so was the presence of widespread microthrombi. This finding suggests that the pathogenesis of this highly infectious virus might be linked to some form of coagulopathy. Further studies should focus on analyzing postmortem findings in a larger number of patients from different demographics in order to obtain more generalizable results. |
format | Online Article Text |
id | pubmed-8648585 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Elsevier B.V. |
record_format | MEDLINE/PubMed |
spelling | pubmed-86485852021-12-07 Postmortem findings in COVID-19 fatalities: A systematic review of current evidence Menezes, Ritesh G. Rizwan, Tehlil Saad Ali, Syed Hassan, Wardah Khetpal, Akash Aqil, Mohammad Madadin, Mohammed Jamal Siddiqi, Tariq Shariq Usman, Muhammad Leg Med (Tokyo) Article The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for the ongoing pandemic of coronavirus disease 2019 (COVID-19). Almost 17 months after the first COVID-19 case was reported, the exact pathogenesis of the virus is still open to interpretation. Postmortem studies have been relatively scarce due to the high infectivity rate of the virus. We systematically reviewed the literature available for studies that reported gross, histological, microscopic, and immunohistochemical findings in COVID-19 fatalities with the aim of reporting any recurrent findings among different demographics. PubMed and Scopus were searched up till the second of May 2021 and 46 studies with a total of 793 patients were shortlisted after the application of inclusion and exclusion criteria. The selected studies reported gross, histological, microscopic, and immunohistochemical autopsy findings in the lungs, heart, liver, gallbladder, bowels, kidney, spleen, bone marrow, lymph nodes, CNS, pancreas, endocrine/exocrine glands, and a few other miscellaneous locations. The SARS-CoV-2 virus was detected in multiple organs and so was the presence of widespread microthrombi. This finding suggests that the pathogenesis of this highly infectious virus might be linked to some form of coagulopathy. Further studies should focus on analyzing postmortem findings in a larger number of patients from different demographics in order to obtain more generalizable results. Elsevier B.V. 2022-02 2021-12-07 /pmc/articles/PMC8648585/ /pubmed/34952452 http://dx.doi.org/10.1016/j.legalmed.2021.102001 Text en © 2021 Elsevier B.V. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
spellingShingle | Article Menezes, Ritesh G. Rizwan, Tehlil Saad Ali, Syed Hassan, Wardah Khetpal, Akash Aqil, Mohammad Madadin, Mohammed Jamal Siddiqi, Tariq Shariq Usman, Muhammad Postmortem findings in COVID-19 fatalities: A systematic review of current evidence |
title | Postmortem findings in COVID-19 fatalities: A systematic review of current evidence |
title_full | Postmortem findings in COVID-19 fatalities: A systematic review of current evidence |
title_fullStr | Postmortem findings in COVID-19 fatalities: A systematic review of current evidence |
title_full_unstemmed | Postmortem findings in COVID-19 fatalities: A systematic review of current evidence |
title_short | Postmortem findings in COVID-19 fatalities: A systematic review of current evidence |
title_sort | postmortem findings in covid-19 fatalities: a systematic review of current evidence |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8648585/ https://www.ncbi.nlm.nih.gov/pubmed/34952452 http://dx.doi.org/10.1016/j.legalmed.2021.102001 |
work_keys_str_mv | AT menezesriteshg postmortemfindingsincovid19fatalitiesasystematicreviewofcurrentevidence AT rizwantehlil postmortemfindingsincovid19fatalitiesasystematicreviewofcurrentevidence AT saadalisyed postmortemfindingsincovid19fatalitiesasystematicreviewofcurrentevidence AT hassanwardah postmortemfindingsincovid19fatalitiesasystematicreviewofcurrentevidence AT khetpalakash postmortemfindingsincovid19fatalitiesasystematicreviewofcurrentevidence AT aqilmohammad postmortemfindingsincovid19fatalitiesasystematicreviewofcurrentevidence AT madadinmohammed postmortemfindingsincovid19fatalitiesasystematicreviewofcurrentevidence AT jamalsiddiqitariq postmortemfindingsincovid19fatalitiesasystematicreviewofcurrentevidence AT shariqusmanmuhammad postmortemfindingsincovid19fatalitiesasystematicreviewofcurrentevidence |