Multifunctional thiosemicarbazones targeting sigma receptors: in vitro and in vivo antitumor activities in pancreatic cancer models

PURPOSE: Association of the metal chelating portion of thiosemicarbazone with the cytotoxic activity of sigma-2 receptors appears a promising strategy for the treatment of pancreatic tumors. Here, we developed a novel sigma-2 receptor targeting thiosemicarbazone (FA4) that incorporates a moiety asso...

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Detalles Bibliográficos
Autores principales: Niso, Mauro, Kopecka, Joanna, Abatematteo, Francesca Serena, Berardi, Francesco, Riganti, Chiara, Abate, Carmen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Netherlands 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8648660/
https://www.ncbi.nlm.nih.gov/pubmed/34586588
http://dx.doi.org/10.1007/s13402-021-00638-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8648660/
https://www.ncbi.nlm.nih.gov/pubmed/34586588
http://dx.doi.org/10.1007/s13402-021-00638-5

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