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Upstream process optimization and micro- and macrocarrier screening for large-scale production of the oncolytic H-1 protoparvovirus

ABSTRACT: The oncolytic virus H-1PV is a promising candidate for various cancer treatments. Therefore, production process needs to be optimized and scaled up for future market release. Currently, the virus is produced with minimum essential medium in 10-layer CellSTACK® chambers with limited scalabi...

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Detalles Bibliográficos
Autores principales:	Wohlfarth, Daniel, Frehtman, Veronika, Müller, Marcus, Vogel, Martin, Phan, Linh Minh Phuc, Brunecker, Adrian, Leuchs, Barbara
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Berlin Heidelberg 2021
Materias:	Biotechnological Products and Process Engineering
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8648687/ https://www.ncbi.nlm.nih.gov/pubmed/34782922 http://dx.doi.org/10.1007/s00253-021-11642-y

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