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Adaptive value of foot-and-mouth disease virus capsid substitutions with opposite effects on particle acid stability

Foot-and-mouth disease virus (FMDV) is a picornavirus that exhibits an extremely acid sensitive capsid. This acid lability is directly related to its mechanism of uncoating triggered by acidification inside cellular endosomes. Using a collection of FMDV mutants we have systematically analyzed the re...

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Detalles Bibliográficos
Autores principales:	Caridi, Flavia, Cañas-Arranz, Rodrigo, Vázquez-Calvo, Ángela, de León, Patricia, Calderón, Katherine I., Domingo, Esteban, Sobrino, Francisco, Martín-Acebes, Miguel A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8648728/ https://www.ncbi.nlm.nih.gov/pubmed/34873184 http://dx.doi.org/10.1038/s41598-021-02757-3

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