Genetically regulated expression in late-onset Alzheimer’s disease implicates risk genes within known and novel loci

Late-onset Alzheimer disease (LOAD) is highly polygenic, with a heritability estimated between 40 and 80%, yet risk variants identified in genome-wide studies explain only ~8% of phenotypic variance. Due to its increased power and interpretability, genetically regulated expression (GReX) analysis is...

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Detalles Bibliográficos
Autores principales: Chen, Hung-Hsin, Petty, Lauren E., Sha, Jin, Zhao, Yi, Kuzma, Amanda, Valladares, Otto, Bush, William, Naj, Adam C., Gamazon, Eric R., Below, Jennifer E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8648734/
https://www.ncbi.nlm.nih.gov/pubmed/34873149
http://dx.doi.org/10.1038/s41398-021-01677-0

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