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Medium levels of transcription and replication related chromosomal instability are associated with poor clinical outcome

Genomic instability (GI) influences treatment efficacy and resistance, and an accurate measure of it is lacking. Current measures of GI are based on counts of specific structural variation (SV) and mutational signatures. Here, we present a holistic approach to measuring GI based on the quantificatio...

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Detalles Bibliográficos
Autores principales:	Benhaddou, Ataaillah, Gaston, Laetitia, Pérot, Gaëlle, Desplat, Nelly, Leroy, Laura, Le Guellec, Sophie, Ben Haddou, Mohamed, Rochaix, Philippe, Valentin, Thibaud, Ferron, Gwenaël, Chevreau, Christine, Bui, Binh, Stoeckle, Eberhard, Le Cesne, Axel, Piperno-Neumann, Sophie, Collin, Françoise, Firmin, Nelly, De Pinieux, Gonzague, Coindre, Jean-Michel, Blay, Jean-Yves, Chibon, Frédéric
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8648741/ https://www.ncbi.nlm.nih.gov/pubmed/34873180 http://dx.doi.org/10.1038/s41598-021-02787-x

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