Reductive inactivation of the hemiaminal pharmacophore for resistance against tetrahydroisoquinoline antibiotics

Antibiotic resistance is becoming one of the major crises, among which hydrolysis reaction is widely employed by bacteria to destroy the reactive pharmacophore. Correspondingly, antibiotic producer has canonically co-evolved this approach with the biosynthetic capability for self-resistance. Here we...

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Detalles Bibliográficos
Autores principales: Wen, Wan-Hong, Zhang, Yue, Zhang, Ying-Ying, Yu, Qian, Jiang, Chu-Chu, Tang, Man-Cheng, Pu, Jin-Yue, Wu, Lian, Zhao, Yi-Lei, Shi, Ting, Zhou, Jiahai, Tang, Gong-Li
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8648761/
https://www.ncbi.nlm.nih.gov/pubmed/34873166
http://dx.doi.org/10.1038/s41467-021-27404-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8648761/
https://www.ncbi.nlm.nih.gov/pubmed/34873166
http://dx.doi.org/10.1038/s41467-021-27404-3

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