Disruption of the PDZ domain–binding motif of the dopamine transporter uniquely alters nanoscale distribution, dopamine homeostasis, and reward motivation

The dopamine (DA) transporter (DAT) is part of a presynaptic multiprotein network involving interactions with scaffold proteins via its C-terminal PDZ domain–binding sequence. Using a mouse model expressing DAT with mutated PDZ-binding sequence (DAT-AAA), we previously demonstrated the importance of...

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Detalles Bibliográficos
Autores principales: Sørensen, Gunnar, Rickhag, Mattias, Leo, Damiana, Lycas, Matthew D., Ridderstrøm, Pernille Herrstedt, Weikop, Pia, Lilja, Jamila H., Rifes, Pedro, Herborg, Freja, Woldbye, David, Wörtwein, Gitta, Gainetdinov, Raul R., Fink-Jensen, Anders, Gether, Ulrik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8648841/
https://www.ncbi.nlm.nih.gov/pubmed/34756883
http://dx.doi.org/10.1016/j.jbc.2021.101361

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