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Matrix stiffness modulates hepatic stellate cell activation into tumor-promoting myofibroblasts via E2F3-dependent signaling and regulates malignant progression

The hepatic stellate cells (HSCs) activation by myofibroblastic differentiation is critical for liver fibrosis. Crosstalk between stromal cells and tumor cells in the microenvironment alters the properties and facilitates the growth and metastasis of tumor cells. How mechanical stimuli originally st...

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Detalles Bibliográficos
Autores principales:	Liu, Zhikui, Mo, Huanye, Liu, Runkun, Niu, Yongshen, Chen, Tianxiang, Xu, Qiuran, Tu, Kangsheng, Yang, Nan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8648844/ https://www.ncbi.nlm.nih.gov/pubmed/34873170 http://dx.doi.org/10.1038/s41419-021-04418-9

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