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A 1-minute blood test detects decreased immune function and increased clinical risk in COVID-19 patients

Upon infection with SARS-CoV-2, the virus that causes COVID-19, most people will develop no or mild symptoms. However, a small percentage of the population will become severely ill, and some will succumb to death. The clinical severity of COVID-19 has a close connection to the dysregulation of the p...

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Autores principales: Deb, Chirajyoti, Salinas, Allan N., Zheng, Tianyu, Middleton, Aurea, Kern, Katelyn, Penoyer, Daleen, Borsadia, Rahul, Hunley, Charles, Abomoelak, Bassam, Mehta, Vijay, Irastorza, Laura, Mehta, Devendra I., Huo, Qun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8648859/
https://www.ncbi.nlm.nih.gov/pubmed/34873223
http://dx.doi.org/10.1038/s41598-021-02863-2
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author Deb, Chirajyoti
Salinas, Allan N.
Zheng, Tianyu
Middleton, Aurea
Kern, Katelyn
Penoyer, Daleen
Borsadia, Rahul
Hunley, Charles
Abomoelak, Bassam
Mehta, Vijay
Irastorza, Laura
Mehta, Devendra I.
Huo, Qun
author_facet Deb, Chirajyoti
Salinas, Allan N.
Zheng, Tianyu
Middleton, Aurea
Kern, Katelyn
Penoyer, Daleen
Borsadia, Rahul
Hunley, Charles
Abomoelak, Bassam
Mehta, Vijay
Irastorza, Laura
Mehta, Devendra I.
Huo, Qun
author_sort Deb, Chirajyoti
collection PubMed
description Upon infection with SARS-CoV-2, the virus that causes COVID-19, most people will develop no or mild symptoms. However, a small percentage of the population will become severely ill, and some will succumb to death. The clinical severity of COVID-19 has a close connection to the dysregulation of the patient’s immune functions. We previously developed a simple, nanoparticle-enabled blood test that can determine the humoral immune status in animals. In this study, we applied this new test to analyze the immune function in relation to disease severity in COVID-19 patients. From the testing of 153 COVID-19 patient samples and 142 negative controls, we detected a drastic decrease of humoral immunity in COVID-19 patients who developed moderate to severe symptoms, but not in patients with no or mild symptoms. The new test may be potentially used to monitor the immunity change and predict the clinical risk of patients with COVID-19.
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spelling pubmed-86488592021-12-08 A 1-minute blood test detects decreased immune function and increased clinical risk in COVID-19 patients Deb, Chirajyoti Salinas, Allan N. Zheng, Tianyu Middleton, Aurea Kern, Katelyn Penoyer, Daleen Borsadia, Rahul Hunley, Charles Abomoelak, Bassam Mehta, Vijay Irastorza, Laura Mehta, Devendra I. Huo, Qun Sci Rep Article Upon infection with SARS-CoV-2, the virus that causes COVID-19, most people will develop no or mild symptoms. However, a small percentage of the population will become severely ill, and some will succumb to death. The clinical severity of COVID-19 has a close connection to the dysregulation of the patient’s immune functions. We previously developed a simple, nanoparticle-enabled blood test that can determine the humoral immune status in animals. In this study, we applied this new test to analyze the immune function in relation to disease severity in COVID-19 patients. From the testing of 153 COVID-19 patient samples and 142 negative controls, we detected a drastic decrease of humoral immunity in COVID-19 patients who developed moderate to severe symptoms, but not in patients with no or mild symptoms. The new test may be potentially used to monitor the immunity change and predict the clinical risk of patients with COVID-19. Nature Publishing Group UK 2021-12-06 /pmc/articles/PMC8648859/ /pubmed/34873223 http://dx.doi.org/10.1038/s41598-021-02863-2 Text en © The Author(s) 2021, corrected publication 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Deb, Chirajyoti
Salinas, Allan N.
Zheng, Tianyu
Middleton, Aurea
Kern, Katelyn
Penoyer, Daleen
Borsadia, Rahul
Hunley, Charles
Abomoelak, Bassam
Mehta, Vijay
Irastorza, Laura
Mehta, Devendra I.
Huo, Qun
A 1-minute blood test detects decreased immune function and increased clinical risk in COVID-19 patients
title A 1-minute blood test detects decreased immune function and increased clinical risk in COVID-19 patients
title_full A 1-minute blood test detects decreased immune function and increased clinical risk in COVID-19 patients
title_fullStr A 1-minute blood test detects decreased immune function and increased clinical risk in COVID-19 patients
title_full_unstemmed A 1-minute blood test detects decreased immune function and increased clinical risk in COVID-19 patients
title_short A 1-minute blood test detects decreased immune function and increased clinical risk in COVID-19 patients
title_sort 1-minute blood test detects decreased immune function and increased clinical risk in covid-19 patients
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8648859/
https://www.ncbi.nlm.nih.gov/pubmed/34873223
http://dx.doi.org/10.1038/s41598-021-02863-2
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