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Single cell atlas for 11 non-model mammals, reptiles and birds
The availability of viral entry factors is a prerequisite for the cross-species transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Large-scale single-cell screening of animal cells could reveal the expression patterns of viral entry genes in different hosts. However, such...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8648889/ https://www.ncbi.nlm.nih.gov/pubmed/34873160 http://dx.doi.org/10.1038/s41467-021-27162-2 |
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| author | Chen, Dongsheng Sun, Jian Zhu, Jiacheng Ding, Xiangning Lan, Tianming Wang, Xiran Wu, Weiying Ou, Zhihua Zhu, Linnan Ding, Peiwen Wang, Haoyu Luo, Lihua Xiang, Rong Wang, Xiaoling Qiu, Jiaying Wang, Shiyou Li, Haimeng Chai, Chaochao Liang, Langchao An, Fuyu Zhang, Le Han, Lei Zhu, Yixin Wang, Feiyue Yuan, Yuting Wu, Wendi Sun, Chengcheng Lu, Haorong Wu, Jihong Sun, Xinghuai Zhang, Shenghai Sahu, Sunil Kumar Liu, Ping Xia, Jun Zhang, Lijing Chen, Haixia Fang, Dongming Zeng, Yuying Wu, Yiquan Cui, Zehua He, Qian Jiang, Sanjie Ma, Xiaoyan Feng, Weimin Xu, Yan Li, Fang Liu, Zhongmin Chen, Lei Chen, Fang Jin, Xin Qiu, Wei Wang, Tianjiao Li, Yang Xing, Xiumei Yang, Huanming Xu, Yanchun Hua, Yan Liu, Yahong Liu, Huan Xu, Xun |
| author_facet | Chen, Dongsheng Sun, Jian Zhu, Jiacheng Ding, Xiangning Lan, Tianming Wang, Xiran Wu, Weiying Ou, Zhihua Zhu, Linnan Ding, Peiwen Wang, Haoyu Luo, Lihua Xiang, Rong Wang, Xiaoling Qiu, Jiaying Wang, Shiyou Li, Haimeng Chai, Chaochao Liang, Langchao An, Fuyu Zhang, Le Han, Lei Zhu, Yixin Wang, Feiyue Yuan, Yuting Wu, Wendi Sun, Chengcheng Lu, Haorong Wu, Jihong Sun, Xinghuai Zhang, Shenghai Sahu, Sunil Kumar Liu, Ping Xia, Jun Zhang, Lijing Chen, Haixia Fang, Dongming Zeng, Yuying Wu, Yiquan Cui, Zehua He, Qian Jiang, Sanjie Ma, Xiaoyan Feng, Weimin Xu, Yan Li, Fang Liu, Zhongmin Chen, Lei Chen, Fang Jin, Xin Qiu, Wei Wang, Tianjiao Li, Yang Xing, Xiumei Yang, Huanming Xu, Yanchun Hua, Yan Liu, Yahong Liu, Huan Xu, Xun |
| author_sort | Chen, Dongsheng |
| collection | PubMed |
| description | The availability of viral entry factors is a prerequisite for the cross-species transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Large-scale single-cell screening of animal cells could reveal the expression patterns of viral entry genes in different hosts. However, such exploration for SARS-CoV-2 remains limited. Here, we perform single-nucleus RNA sequencing for 11 non-model species, including pets (cat, dog, hamster, and lizard), livestock (goat and rabbit), poultry (duck and pigeon), and wildlife (pangolin, tiger, and deer), and investigated the co-expression of ACE2 and TMPRSS2. Furthermore, cross-species analysis of the lung cell atlas of the studied mammals, reptiles, and birds reveals core developmental programs, critical connectomes, and conserved regulatory circuits among these evolutionarily distant species. Overall, our work provides a compendium of gene expression profiles for non-model animals, which could be employed to identify potential SARS-CoV-2 target cells and putative zoonotic reservoirs. |
| format | Online Article Text |
| id | pubmed-8648889 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2021 |
| publisher | Nature Publishing Group UK |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-86488892021-12-27 Single cell atlas for 11 non-model mammals, reptiles and birds Chen, Dongsheng Sun, Jian Zhu, Jiacheng Ding, Xiangning Lan, Tianming Wang, Xiran Wu, Weiying Ou, Zhihua Zhu, Linnan Ding, Peiwen Wang, Haoyu Luo, Lihua Xiang, Rong Wang, Xiaoling Qiu, Jiaying Wang, Shiyou Li, Haimeng Chai, Chaochao Liang, Langchao An, Fuyu Zhang, Le Han, Lei Zhu, Yixin Wang, Feiyue Yuan, Yuting Wu, Wendi Sun, Chengcheng Lu, Haorong Wu, Jihong Sun, Xinghuai Zhang, Shenghai Sahu, Sunil Kumar Liu, Ping Xia, Jun Zhang, Lijing Chen, Haixia Fang, Dongming Zeng, Yuying Wu, Yiquan Cui, Zehua He, Qian Jiang, Sanjie Ma, Xiaoyan Feng, Weimin Xu, Yan Li, Fang Liu, Zhongmin Chen, Lei Chen, Fang Jin, Xin Qiu, Wei Wang, Tianjiao Li, Yang Xing, Xiumei Yang, Huanming Xu, Yanchun Hua, Yan Liu, Yahong Liu, Huan Xu, Xun Nat Commun Article The availability of viral entry factors is a prerequisite for the cross-species transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Large-scale single-cell screening of animal cells could reveal the expression patterns of viral entry genes in different hosts. However, such exploration for SARS-CoV-2 remains limited. Here, we perform single-nucleus RNA sequencing for 11 non-model species, including pets (cat, dog, hamster, and lizard), livestock (goat and rabbit), poultry (duck and pigeon), and wildlife (pangolin, tiger, and deer), and investigated the co-expression of ACE2 and TMPRSS2. Furthermore, cross-species analysis of the lung cell atlas of the studied mammals, reptiles, and birds reveals core developmental programs, critical connectomes, and conserved regulatory circuits among these evolutionarily distant species. Overall, our work provides a compendium of gene expression profiles for non-model animals, which could be employed to identify potential SARS-CoV-2 target cells and putative zoonotic reservoirs. Nature Publishing Group UK 2021-12-06 /pmc/articles/PMC8648889/ /pubmed/34873160 http://dx.doi.org/10.1038/s41467-021-27162-2 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
| spellingShingle | Article Chen, Dongsheng Sun, Jian Zhu, Jiacheng Ding, Xiangning Lan, Tianming Wang, Xiran Wu, Weiying Ou, Zhihua Zhu, Linnan Ding, Peiwen Wang, Haoyu Luo, Lihua Xiang, Rong Wang, Xiaoling Qiu, Jiaying Wang, Shiyou Li, Haimeng Chai, Chaochao Liang, Langchao An, Fuyu Zhang, Le Han, Lei Zhu, Yixin Wang, Feiyue Yuan, Yuting Wu, Wendi Sun, Chengcheng Lu, Haorong Wu, Jihong Sun, Xinghuai Zhang, Shenghai Sahu, Sunil Kumar Liu, Ping Xia, Jun Zhang, Lijing Chen, Haixia Fang, Dongming Zeng, Yuying Wu, Yiquan Cui, Zehua He, Qian Jiang, Sanjie Ma, Xiaoyan Feng, Weimin Xu, Yan Li, Fang Liu, Zhongmin Chen, Lei Chen, Fang Jin, Xin Qiu, Wei Wang, Tianjiao Li, Yang Xing, Xiumei Yang, Huanming Xu, Yanchun Hua, Yan Liu, Yahong Liu, Huan Xu, Xun Single cell atlas for 11 non-model mammals, reptiles and birds |
| title | Single cell atlas for 11 non-model mammals, reptiles and birds |
| title_full | Single cell atlas for 11 non-model mammals, reptiles and birds |
| title_fullStr | Single cell atlas for 11 non-model mammals, reptiles and birds |
| title_full_unstemmed | Single cell atlas for 11 non-model mammals, reptiles and birds |
| title_short | Single cell atlas for 11 non-model mammals, reptiles and birds |
| title_sort | single cell atlas for 11 non-model mammals, reptiles and birds |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8648889/ https://www.ncbi.nlm.nih.gov/pubmed/34873160 http://dx.doi.org/10.1038/s41467-021-27162-2 |
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