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Diagnostic and Prognostic Significance of serum miR-18a-5p in Patients with Atherosclerosis
Atherosclerosis (AS) is a common vascular disease with great harm. The current study examined the expression pattern of miR-18a-5p in AS patients, and explored its clinical values. 110 AS patients and 68 healthy controls were collected clinically, and the expression pattern of miR-18a-5p in the seru...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8649087/ https://www.ncbi.nlm.nih.gov/pubmed/34841929 http://dx.doi.org/10.1177/10760296211050642 |
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author | Teng, PingPing Liu, Yonglei Zhang, Meng Ji, Wanli |
author_facet | Teng, PingPing Liu, Yonglei Zhang, Meng Ji, Wanli |
author_sort | Teng, PingPing |
collection | PubMed |
description | Atherosclerosis (AS) is a common vascular disease with great harm. The current study examined the expression pattern of miR-18a-5p in AS patients, and explored its clinical values. 110 AS patients and 68 healthy controls were collected clinically, and the expression pattern of miR-18a-5p in the serum of AS patients was detected using qRT-PCR. All AS patients were followed up for five years to record the adverse cardiovascular events. ROC and Kaplan-Meier (K-M) curve were plotted to assess the diagnostic ability. The multiple Cox regression analysis was performed for independent influencing factors analysis. MiR-18a-5p was at high expression in AS patients, and showed positive correlation with the CIMT value (r = 0.789, P < .001). ROC curve suggested the high diagnostic value of serum miR-18a-5p for AS, with the AUC of 0.894. The diagnostic specificity and sensitivity were 86.8% and 79.1%, respectively. K-M plot demonstrated that cases with high miR-18a-5p levels were more likely to suffer from cardiovascular events, and it is an independent influence factor for the poor clinical outcome. Serum miR-18a-5p serves as a promising biomarker for AS diagnosis, and is related to the occurrence of adverse cardiovascular events. |
format | Online Article Text |
id | pubmed-8649087 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-86490872021-12-08 Diagnostic and Prognostic Significance of serum miR-18a-5p in Patients with Atherosclerosis Teng, PingPing Liu, Yonglei Zhang, Meng Ji, Wanli Clin Appl Thromb Hemost Original Manuscript Atherosclerosis (AS) is a common vascular disease with great harm. The current study examined the expression pattern of miR-18a-5p in AS patients, and explored its clinical values. 110 AS patients and 68 healthy controls were collected clinically, and the expression pattern of miR-18a-5p in the serum of AS patients was detected using qRT-PCR. All AS patients were followed up for five years to record the adverse cardiovascular events. ROC and Kaplan-Meier (K-M) curve were plotted to assess the diagnostic ability. The multiple Cox regression analysis was performed for independent influencing factors analysis. MiR-18a-5p was at high expression in AS patients, and showed positive correlation with the CIMT value (r = 0.789, P < .001). ROC curve suggested the high diagnostic value of serum miR-18a-5p for AS, with the AUC of 0.894. The diagnostic specificity and sensitivity were 86.8% and 79.1%, respectively. K-M plot demonstrated that cases with high miR-18a-5p levels were more likely to suffer from cardiovascular events, and it is an independent influence factor for the poor clinical outcome. Serum miR-18a-5p serves as a promising biomarker for AS diagnosis, and is related to the occurrence of adverse cardiovascular events. SAGE Publications 2021-11-29 /pmc/articles/PMC8649087/ /pubmed/34841929 http://dx.doi.org/10.1177/10760296211050642 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
spellingShingle | Original Manuscript Teng, PingPing Liu, Yonglei Zhang, Meng Ji, Wanli Diagnostic and Prognostic Significance of serum miR-18a-5p in Patients with Atherosclerosis |
title | Diagnostic and Prognostic Significance of serum miR-18a-5p in Patients with Atherosclerosis |
title_full | Diagnostic and Prognostic Significance of serum miR-18a-5p in Patients with Atherosclerosis |
title_fullStr | Diagnostic and Prognostic Significance of serum miR-18a-5p in Patients with Atherosclerosis |
title_full_unstemmed | Diagnostic and Prognostic Significance of serum miR-18a-5p in Patients with Atherosclerosis |
title_short | Diagnostic and Prognostic Significance of serum miR-18a-5p in Patients with Atherosclerosis |
title_sort | diagnostic and prognostic significance of serum mir-18a-5p in patients with atherosclerosis |
topic | Original Manuscript |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8649087/ https://www.ncbi.nlm.nih.gov/pubmed/34841929 http://dx.doi.org/10.1177/10760296211050642 |
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