Enhanced Heart Failure in Redox‐Dead Cys17Ser PKARIα Knock‐In Mice

BACKGROUND: PKARIα (protein kinase A type I‐α regulatory subunit) is redox‐active independent of its physiologic agonist cAMP. However, it is unknown whether this alternative mechanism of PKARIα activation may be of relevance to cardiac excitation–contraction coupling. METHODS AND RESULTS: We used a...

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Detalles Bibliográficos
Autores principales: Islam, M. M. Towhidul, Tarnowski, Daniel, Zhang, Min, Trum, Maximilian, Lebek, Simon, Mustroph, Julian, Daniel, Henriette, Moellencamp, Johanna, Pabel, Steffen, Sossalla, Samuel, El‐Armouche, Ali, Nikolaev, Viacheslav O., Shah, Ajay M., Eaton, Philip, Maier, Lars S., Sag, Can Martin, Wagner, Stefan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8649132/
https://www.ncbi.nlm.nih.gov/pubmed/34583520
http://dx.doi.org/10.1161/JAHA.121.021985

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