Termination Based on Event Accrual in Per Protocol Versus Intention to Treat in the ROCKET AF Trial

BACKGROUND: In event‐driven clinical trials, study termination is based on accrual of a target number of primary efficacy events. For noninferiority trials in which superiority is conditionally examined, the ideal cohort in which to track event accrual is unclear. We used data from the ROCKET AF (Ri...

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Detalles Bibliográficos
Autores principales: Carnicelli, Anthony P., Hellkamp, Anne S., Mahaffey, Kenneth W., Singer, Daniel E., Breithardt, Günter, Halperin, Jonathan L., Hankey, Graeme J., Piccini, Jonathan P., Becker, Richard C., Nessel, Christopher C., Berkowitz, Scott D., Fox, Keith A. A., Califf, Robert M., Patel, Manesh R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8649140/
https://www.ncbi.nlm.nih.gov/pubmed/34569249
http://dx.doi.org/10.1161/JAHA.121.022485

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