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Association of Rosacea With Cardiovascular Disease: A Retrospective Cohort Study

BACKGROUND: There is emerging evidence that rosacea, a chronic cutaneous inflammatory disease, is associated with various systemic diseases. However, its association with cardiovascular disease (CVD) remains controversial. We aimed to investigate whether patients with rosacea are at increased risk o...

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Autores principales: Choi, Daein, Choi, Sungjun, Choi, Seulggie, Park, Sang Min, Yoon, Hyun‐Sun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8649155/
https://www.ncbi.nlm.nih.gov/pubmed/34558290
http://dx.doi.org/10.1161/JAHA.120.020671
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author Choi, Daein
Choi, Sungjun
Choi, Seulggie
Park, Sang Min
Yoon, Hyun‐Sun
author_facet Choi, Daein
Choi, Sungjun
Choi, Seulggie
Park, Sang Min
Yoon, Hyun‐Sun
author_sort Choi, Daein
collection PubMed
description BACKGROUND: There is emerging evidence that rosacea, a chronic cutaneous inflammatory disease, is associated with various systemic diseases. However, its association with cardiovascular disease (CVD) remains controversial. We aimed to investigate whether patients with rosacea are at increased risk of developing CVD. METHODS AND RESULTS: This retrospective cohort study from the Korean National Health Insurance Service‐Health Screening Cohort included patients with newly diagnosed rosacea (n=2681) and age‐, sex‐, and index year–matched reference populations without rosacea (n=26 810) between 2003 and 2014. The primary outcome was subsequent CVD including coronary heart disease and stroke. Multivariable Cox regression analyses were used to evaluate adjusted hazard ratios for subsequent CVD adjusted for major risk factors of CVD. Compared with the reference population (13 410 women; mean [SD] age, 57.7 [9.2] years), patients with rosacea (1341 women; mean [SD] age, 57.7 [9.2] years) displayed an increased risk for CVD (adjusted hazard ratios, 1.20; 95% CI, 1.03–1.40) and coronary heart disease (adjusted hazard ratios, 1.29; 95% CI, 1.05–1.60). The risk for stroke was not significantly elevated (adjusted hazard ratios, 1.12; 95% CI, 0.91–1.37). CONCLUSIONS: This study suggests that patients with rosacea are more likely to develop subsequent CVD. Proper education for patients with rosacea to manage other modifiable risk factors of CVD along with rosacea is needed.
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spelling pubmed-86491552022-03-21 Association of Rosacea With Cardiovascular Disease: A Retrospective Cohort Study Choi, Daein Choi, Sungjun Choi, Seulggie Park, Sang Min Yoon, Hyun‐Sun J Am Heart Assoc Original Research BACKGROUND: There is emerging evidence that rosacea, a chronic cutaneous inflammatory disease, is associated with various systemic diseases. However, its association with cardiovascular disease (CVD) remains controversial. We aimed to investigate whether patients with rosacea are at increased risk of developing CVD. METHODS AND RESULTS: This retrospective cohort study from the Korean National Health Insurance Service‐Health Screening Cohort included patients with newly diagnosed rosacea (n=2681) and age‐, sex‐, and index year–matched reference populations without rosacea (n=26 810) between 2003 and 2014. The primary outcome was subsequent CVD including coronary heart disease and stroke. Multivariable Cox regression analyses were used to evaluate adjusted hazard ratios for subsequent CVD adjusted for major risk factors of CVD. Compared with the reference population (13 410 women; mean [SD] age, 57.7 [9.2] years), patients with rosacea (1341 women; mean [SD] age, 57.7 [9.2] years) displayed an increased risk for CVD (adjusted hazard ratios, 1.20; 95% CI, 1.03–1.40) and coronary heart disease (adjusted hazard ratios, 1.29; 95% CI, 1.05–1.60). The risk for stroke was not significantly elevated (adjusted hazard ratios, 1.12; 95% CI, 0.91–1.37). CONCLUSIONS: This study suggests that patients with rosacea are more likely to develop subsequent CVD. Proper education for patients with rosacea to manage other modifiable risk factors of CVD along with rosacea is needed. John Wiley and Sons Inc. 2021-09-24 /pmc/articles/PMC8649155/ /pubmed/34558290 http://dx.doi.org/10.1161/JAHA.120.020671 Text en © 2021 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Original Research
Choi, Daein
Choi, Sungjun
Choi, Seulggie
Park, Sang Min
Yoon, Hyun‐Sun
Association of Rosacea With Cardiovascular Disease: A Retrospective Cohort Study
title Association of Rosacea With Cardiovascular Disease: A Retrospective Cohort Study
title_full Association of Rosacea With Cardiovascular Disease: A Retrospective Cohort Study
title_fullStr Association of Rosacea With Cardiovascular Disease: A Retrospective Cohort Study
title_full_unstemmed Association of Rosacea With Cardiovascular Disease: A Retrospective Cohort Study
title_short Association of Rosacea With Cardiovascular Disease: A Retrospective Cohort Study
title_sort association of rosacea with cardiovascular disease: a retrospective cohort study
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8649155/
https://www.ncbi.nlm.nih.gov/pubmed/34558290
http://dx.doi.org/10.1161/JAHA.120.020671
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