TP53 loss initiates chromosomal instability in fallopian tube epithelial cells

High-grade serous ovarian cancer (HGSOC) originates in the fallopian tube epithelium and is characterized by ubiquitous TP53 mutation and extensive chromosomal instability (CIN). However, direct causes of CIN, such as mutations in DNA replication and mitosis genes, are rare in HGSOC. We therefore as...

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Detalles Bibliográficos
Autores principales: Bronder, Daniel, Tighe, Anthony, Wangsa, Darawalee, Zong, Dali, Meyer, Thomas J., Wardenaar, René, Minshall, Paul, Hirsch, Daniela, Heselmeyer-Haddad, Kerstin, Nelson, Louisa, Spierings, Diana, McGrail, Joanne C., Cam, Maggie, Nussenzweig, André, Foijer, Floris, Ried, Thomas, Taylor, Stephen S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8649171/
https://www.ncbi.nlm.nih.gov/pubmed/34569598
http://dx.doi.org/10.1242/dmm.049001

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8649171/
https://www.ncbi.nlm.nih.gov/pubmed/34569598
http://dx.doi.org/10.1242/dmm.049001

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