Excessive Hypoxia‐Inducible Factor‐1α Expression Induces Cardiac Rupture via p53‐Dependent Apoptosis After Myocardial Infarction

BACKGROUND: Apoptosis plays a pivotal role in cardiac rupture after myocardial infarction (MI), and p53 is a key molecule in apoptosis during cardiac rupture. Hif‐1α (hypoxia‐inducible factor‐1α), upregulated under hypoxia, is a known p53 inducer. However, the role of Hif‐1α in the regulatory mechan...

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Detalles Bibliográficos
Autores principales: Ikeda, Masataka, Ide, Tomomi, Tadokoro, Tomonori, Miyamoto, Hiroko Deguchi, Ikeda, Soichiro, Okabe, Kosuke, Ishikita, Akihito, Sato, Midori, Abe, Ko, Furusawa, Shun, Ishimaru, Kosei, Matsushima, Shouji, Tsutsui, Hiroyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8649270/
https://www.ncbi.nlm.nih.gov/pubmed/34472375
http://dx.doi.org/10.1161/JAHA.121.020895

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8649270/
https://www.ncbi.nlm.nih.gov/pubmed/34472375
http://dx.doi.org/10.1161/JAHA.121.020895

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