Acute Genetic Ablation of Cardiac Sodium/Calcium Exchange in Adult Mice: Implications for Cardiomyocyte Calcium Regulation, Cardioprotection, and Arrhythmia

BACKGROUND: Sodium‐calcium (Ca(2+)) exchanger isoform 1 (NCX1) is the dominant Ca(2+) efflux mechanism in cardiomyocytes and is critical to maintaining Ca(2+) homeostasis during excitation‐contraction coupling. NCX1 activity has been implicated in the pathogenesis of cardiovascular diseases, but a l...

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Detalles Bibliográficos
Autores principales: Lotteau, Sabine, Zhang, Rui, Hazan, Adina, Grabar, Christina, Gonzalez, Devina, Aynaszyan, Stephan, Philipson, Kenneth D., Ottolia, Michela, Goldhaber, Joshua I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8649274/
https://www.ncbi.nlm.nih.gov/pubmed/34472363
http://dx.doi.org/10.1161/JAHA.120.019273

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