ATP1A3‐Encoded Sodium‐Potassium ATPase Subunit Alpha 3 D801N Variant Is Associated With Shortened QT Interval and Predisposition to Ventricular Fibrillation Preceded by Bradycardia

BACKGROUND: Pathogenic variation in the ATP1A3‐encoded sodium‐potassium ATPase, ATP1A3, is responsible for alternating hemiplegia of childhood (AHC). Although these patients experience a high rate of sudden unexpected death in epilepsy, the pathophysiologic basis for this risk remains unknown. The o...

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Detalles Bibliográficos
Autores principales: Moya‐Mendez, Mary E., Ogbonna, Chiagoziem, Ezekian, Jordan E., Rosamilia, Michael B., Prange, Lyndsey, de la Uz, Caridad, Kim, Jeffrey J., Howard, Taylor, Garcia, John, Nussbaum, Robert, Truty, Rebecca, Callis, Thomas E., Funk, Emily, Heyes, Matthew, Dear, Guy de Lisle, Carboni, Michael P., Idriss, Salim F., Mikati, Mohamad A., Landstrom, Andrew P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8649289/
https://www.ncbi.nlm.nih.gov/pubmed/34459253
http://dx.doi.org/10.1161/JAHA.120.019887

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