Investigator-Driven Randomised Controlled Trial of Cefiderocol versus Standard Therapy for Healthcare-Associated and Hospital-Acquired Gram-negative Bloodstream Infection: Study protocol (the GAME CHANGER trial): study protocol for an open-label, randomised controlled trial

BACKGROUND: Increasing rates of antibiotic resistance in Gram-negative organisms due to the presence of extended-spectrum beta-lactamases (ESBL), hyperproduction of AmpC enzymes, carbapenemases and other mechanisms of resistance are identified in common hospital- and healthcare-associated pathogens...

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Detalles Bibliográficos
Autores principales: Wright, Hugh, Harris, Patrick N. A., Chatfield, Mark D., Lye, David, Henderson, Andrew, Harris-Brown, Tiffany, Donaldson, Anna, Paterson, David L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Study Protocol
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8649313/
https://www.ncbi.nlm.nih.gov/pubmed/34876196
http://dx.doi.org/10.1186/s13063-021-05870-w

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