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Underutilization of diagnostic assays for celiac disease in Korea

BACKGROUND: Test utilization for the diagnosis of celiac disease may affect the prevalence and incidence of the disease in Korea. We aimed to investigate the test utilization of serological biomarkers for celiac disease in Korea. METHODS: We retrospectively investigated the test utilization of tissu...

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Detalles Bibliográficos
Autores principales: Choi, Rihwa, Lee, Sang Gon, Lee, Eun Hee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8649377/
https://www.ncbi.nlm.nih.gov/pubmed/34689365
http://dx.doi.org/10.1002/jcla.23913
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author Choi, Rihwa
Lee, Sang Gon
Lee, Eun Hee
author_facet Choi, Rihwa
Lee, Sang Gon
Lee, Eun Hee
author_sort Choi, Rihwa
collection PubMed
description BACKGROUND: Test utilization for the diagnosis of celiac disease may affect the prevalence and incidence of the disease in Korea. We aimed to investigate the test utilization of serological biomarkers for celiac disease in Korea. METHODS: We retrospectively investigated the test utilization of tissue transglutaminase IgA, gliadin IgA and IgG, and endomysial IgA antibody (Ab) assays between January 2011 and June 2020. RESULTS: During a nine‐year‐and‐six‐month study period, overall 307,322,606 clinical tests were requested from different clinical settings, such as local clinics, hospitals, university hospitals, and tertiary medical centers. Among them, only 58 tissue transglutaminase IgA, 22 gliadin IgA, 12 gliadin IgG, and 16 endomysial IgA Ab tests were performed on 79 Korean patients. Among them, one patient had positive transglutaminase IgA Ab result (1.3%). CONCLUSION: Low prevalence and incidence of celiac disease in Korea may be due to an underutilization of diagnostic assays.
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spelling pubmed-86493772021-12-20 Underutilization of diagnostic assays for celiac disease in Korea Choi, Rihwa Lee, Sang Gon Lee, Eun Hee J Clin Lab Anal Research Articles BACKGROUND: Test utilization for the diagnosis of celiac disease may affect the prevalence and incidence of the disease in Korea. We aimed to investigate the test utilization of serological biomarkers for celiac disease in Korea. METHODS: We retrospectively investigated the test utilization of tissue transglutaminase IgA, gliadin IgA and IgG, and endomysial IgA antibody (Ab) assays between January 2011 and June 2020. RESULTS: During a nine‐year‐and‐six‐month study period, overall 307,322,606 clinical tests were requested from different clinical settings, such as local clinics, hospitals, university hospitals, and tertiary medical centers. Among them, only 58 tissue transglutaminase IgA, 22 gliadin IgA, 12 gliadin IgG, and 16 endomysial IgA Ab tests were performed on 79 Korean patients. Among them, one patient had positive transglutaminase IgA Ab result (1.3%). CONCLUSION: Low prevalence and incidence of celiac disease in Korea may be due to an underutilization of diagnostic assays. John Wiley and Sons Inc. 2021-10-24 /pmc/articles/PMC8649377/ /pubmed/34689365 http://dx.doi.org/10.1002/jcla.23913 Text en © 2021 The Authors. Journal of Clinical Laboratory Analysis published by Wiley Periodicals LLC. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Articles
Choi, Rihwa
Lee, Sang Gon
Lee, Eun Hee
Underutilization of diagnostic assays for celiac disease in Korea
title Underutilization of diagnostic assays for celiac disease in Korea
title_full Underutilization of diagnostic assays for celiac disease in Korea
title_fullStr Underutilization of diagnostic assays for celiac disease in Korea
title_full_unstemmed Underutilization of diagnostic assays for celiac disease in Korea
title_short Underutilization of diagnostic assays for celiac disease in Korea
title_sort underutilization of diagnostic assays for celiac disease in korea
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8649377/
https://www.ncbi.nlm.nih.gov/pubmed/34689365
http://dx.doi.org/10.1002/jcla.23913
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