Cargando…

Secretory phospholipase A2 in SARS-CoV-2 infection and multisystem inflammatory syndrome in children (MIS-C)

Secretory phospholipase 2 (sPLA2) acts as a mediator between proximal and distal events of the inflammatory cascade. Its role in SARS-CoV-2 infection is unknown, but could contribute to COVID-19 inflammasome activation and cellular damage. We present the first report of plasma sPLA2 levels in adults...

Descripción completa

Detalles Bibliográficos
Autores principales: Kuypers, Frans A, Rostad, Christina A, Anderson, Evan J, Chahroudi, Ann, Jaggi, Preeti, Wrammert, Jens, Mantus, Grace, Basu, Rajit, Harris, Frank, Hanberry, Bradley, Camacho-Gonzalez, Andres, Manoranjithan, Shaminy, Vos, Miriam, Brown, Lou Ann, Morris, Claudia R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8649422/
https://www.ncbi.nlm.nih.gov/pubmed/34255566
http://dx.doi.org/10.1177/15353702211028560
_version_ 1784610992483729408
author Kuypers, Frans A
Rostad, Christina A
Anderson, Evan J
Chahroudi, Ann
Jaggi, Preeti
Wrammert, Jens
Mantus, Grace
Basu, Rajit
Harris, Frank
Hanberry, Bradley
Camacho-Gonzalez, Andres
Manoranjithan, Shaminy
Vos, Miriam
Brown, Lou Ann
Morris, Claudia R
author_facet Kuypers, Frans A
Rostad, Christina A
Anderson, Evan J
Chahroudi, Ann
Jaggi, Preeti
Wrammert, Jens
Mantus, Grace
Basu, Rajit
Harris, Frank
Hanberry, Bradley
Camacho-Gonzalez, Andres
Manoranjithan, Shaminy
Vos, Miriam
Brown, Lou Ann
Morris, Claudia R
author_sort Kuypers, Frans A
collection PubMed
description Secretory phospholipase 2 (sPLA2) acts as a mediator between proximal and distal events of the inflammatory cascade. Its role in SARS-CoV-2 infection is unknown, but could contribute to COVID-19 inflammasome activation and cellular damage. We present the first report of plasma sPLA2 levels in adults and children with COVID-19 compared with controls. Currently asymptomatic adults with a history of recent COVID-19 infection (≥4 weeks before) identified by SARS-CoV-2 IgG antibodies had sPLA2 levels similar to those who were seronegative (9 ± 6 vs.17 ± 28 ng/mL, P = 0.26). In contrast, children hospitalized with severe COVID-19 had significantly elevated sPLA2 compared with those with mild or asymptomatic SARS-CoV-2 infection (269 ± 137 vs. 2 ± 3 ng/mL, P = 0.01). Among children hospitalized with multisystem inflammatory syndrome in children (MIS-C), all had severe disease requiring pediatric intensive care unit (PICU) admission. sPLA2 levels were significantly higher in those with acute illness <10 days versus convalescent disease ≥10 days (540 ± 510 vs. 2 ± 1, P = 0.04). Thus, sPLA2 levels correlated with COVID-19 severity and acute MIS-C in children, implicating a role in inflammasome activation and disease pathogenesis. sPLA2 may be a useful biomarker to stratify risk and guide patient management for children with acute COVID-19 and MIS-C. Therapeutic compounds targeting sPLA2 and inflammasome activation warrant consideration.
format Online
Article
Text
id pubmed-8649422
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher SAGE Publications
record_format MEDLINE/PubMed
spelling pubmed-86494222021-12-08 Secretory phospholipase A2 in SARS-CoV-2 infection and multisystem inflammatory syndrome in children (MIS-C) Kuypers, Frans A Rostad, Christina A Anderson, Evan J Chahroudi, Ann Jaggi, Preeti Wrammert, Jens Mantus, Grace Basu, Rajit Harris, Frank Hanberry, Bradley Camacho-Gonzalez, Andres Manoranjithan, Shaminy Vos, Miriam Brown, Lou Ann Morris, Claudia R Exp Biol Med (Maywood) Original Research Secretory phospholipase 2 (sPLA2) acts as a mediator between proximal and distal events of the inflammatory cascade. Its role in SARS-CoV-2 infection is unknown, but could contribute to COVID-19 inflammasome activation and cellular damage. We present the first report of plasma sPLA2 levels in adults and children with COVID-19 compared with controls. Currently asymptomatic adults with a history of recent COVID-19 infection (≥4 weeks before) identified by SARS-CoV-2 IgG antibodies had sPLA2 levels similar to those who were seronegative (9 ± 6 vs.17 ± 28 ng/mL, P = 0.26). In contrast, children hospitalized with severe COVID-19 had significantly elevated sPLA2 compared with those with mild or asymptomatic SARS-CoV-2 infection (269 ± 137 vs. 2 ± 3 ng/mL, P = 0.01). Among children hospitalized with multisystem inflammatory syndrome in children (MIS-C), all had severe disease requiring pediatric intensive care unit (PICU) admission. sPLA2 levels were significantly higher in those with acute illness <10 days versus convalescent disease ≥10 days (540 ± 510 vs. 2 ± 1, P = 0.04). Thus, sPLA2 levels correlated with COVID-19 severity and acute MIS-C in children, implicating a role in inflammasome activation and disease pathogenesis. sPLA2 may be a useful biomarker to stratify risk and guide patient management for children with acute COVID-19 and MIS-C. Therapeutic compounds targeting sPLA2 and inflammasome activation warrant consideration. SAGE Publications 2021-07-13 2021-12 /pmc/articles/PMC8649422/ /pubmed/34255566 http://dx.doi.org/10.1177/15353702211028560 Text en © 2021 by the Society for Experimental Biology and Medicine https://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution 4.0 License (https://creativecommons.org/licenses/by/4.0/) which permits any use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Original Research
Kuypers, Frans A
Rostad, Christina A
Anderson, Evan J
Chahroudi, Ann
Jaggi, Preeti
Wrammert, Jens
Mantus, Grace
Basu, Rajit
Harris, Frank
Hanberry, Bradley
Camacho-Gonzalez, Andres
Manoranjithan, Shaminy
Vos, Miriam
Brown, Lou Ann
Morris, Claudia R
Secretory phospholipase A2 in SARS-CoV-2 infection and multisystem inflammatory syndrome in children (MIS-C)
title Secretory phospholipase A2 in SARS-CoV-2 infection and multisystem inflammatory syndrome in children (MIS-C)
title_full Secretory phospholipase A2 in SARS-CoV-2 infection and multisystem inflammatory syndrome in children (MIS-C)
title_fullStr Secretory phospholipase A2 in SARS-CoV-2 infection and multisystem inflammatory syndrome in children (MIS-C)
title_full_unstemmed Secretory phospholipase A2 in SARS-CoV-2 infection and multisystem inflammatory syndrome in children (MIS-C)
title_short Secretory phospholipase A2 in SARS-CoV-2 infection and multisystem inflammatory syndrome in children (MIS-C)
title_sort secretory phospholipase a2 in sars-cov-2 infection and multisystem inflammatory syndrome in children (mis-c)
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8649422/
https://www.ncbi.nlm.nih.gov/pubmed/34255566
http://dx.doi.org/10.1177/15353702211028560
work_keys_str_mv AT kuypersfransa secretoryphospholipasea2insarscov2infectionandmultisysteminflammatorysyndromeinchildrenmisc
AT rostadchristinaa secretoryphospholipasea2insarscov2infectionandmultisysteminflammatorysyndromeinchildrenmisc
AT andersonevanj secretoryphospholipasea2insarscov2infectionandmultisysteminflammatorysyndromeinchildrenmisc
AT chahroudiann secretoryphospholipasea2insarscov2infectionandmultisysteminflammatorysyndromeinchildrenmisc
AT jaggipreeti secretoryphospholipasea2insarscov2infectionandmultisysteminflammatorysyndromeinchildrenmisc
AT wrammertjens secretoryphospholipasea2insarscov2infectionandmultisysteminflammatorysyndromeinchildrenmisc
AT mantusgrace secretoryphospholipasea2insarscov2infectionandmultisysteminflammatorysyndromeinchildrenmisc
AT basurajit secretoryphospholipasea2insarscov2infectionandmultisysteminflammatorysyndromeinchildrenmisc
AT harrisfrank secretoryphospholipasea2insarscov2infectionandmultisysteminflammatorysyndromeinchildrenmisc
AT hanberrybradley secretoryphospholipasea2insarscov2infectionandmultisysteminflammatorysyndromeinchildrenmisc
AT camachogonzalezandres secretoryphospholipasea2insarscov2infectionandmultisysteminflammatorysyndromeinchildrenmisc
AT manoranjithanshaminy secretoryphospholipasea2insarscov2infectionandmultisysteminflammatorysyndromeinchildrenmisc
AT vosmiriam secretoryphospholipasea2insarscov2infectionandmultisysteminflammatorysyndromeinchildrenmisc
AT brownlouann secretoryphospholipasea2insarscov2infectionandmultisysteminflammatorysyndromeinchildrenmisc
AT morrisclaudiar secretoryphospholipasea2insarscov2infectionandmultisysteminflammatorysyndromeinchildrenmisc