Leg paralysis after AstraZeneca COVID-19 vaccination diagnosed as neuralgic amyotrophy of the lumbosacral plexus: a case report

The ongoing global administration of vaccines for coronavirus disease 2019 (COVID-19) means that increasing numbers of patients are likely to present with post-vaccination complications. We describe the first reported case of neuralgic amyotrophy (NA) involving the lumbosacral plexus occurring after...

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Detalles Bibliográficos
Autores principales: Kim, Se Il, Seok, Hung Youl, Yi, Jaehyuck, Cho, Jang Hyuk
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2021
Materias:
Case Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8649466/
https://www.ncbi.nlm.nih.gov/pubmed/34816739
http://dx.doi.org/10.1177/03000605211056783
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author Kim, Se Il
Seok, Hung Youl
Yi, Jaehyuck
Cho, Jang Hyuk
author_facet Kim, Se Il
Seok, Hung Youl
Yi, Jaehyuck
Cho, Jang Hyuk
author_sort Kim, Se Il
collection PubMed
description The ongoing global administration of vaccines for coronavirus disease 2019 (COVID-19) means that increasing numbers of patients are likely to present with post-vaccination complications. We describe the first reported case of neuralgic amyotrophy (NA) involving the lumbosacral plexus occurring after AstraZeneca COVID-19 vaccination. The patient presented with acute-onset leg paralysis following administration of the vaccine. Based on the clinical, electrodiagnostic, and radiologic findings, the patient was diagnosed with post-vaccination NA. We speculate that the COVID-19 vaccine elicited an immune-mediated inflammatory response to the injected antigen due to inflammatory immunity in a patient with predisposed susceptibility to NA.
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spelling pubmed-86494662021-12-08 Leg paralysis after AstraZeneca COVID-19 vaccination diagnosed as neuralgic amyotrophy of the lumbosacral plexus: a case report Kim, Se Il Seok, Hung Youl Yi, Jaehyuck Cho, Jang Hyuk J Int Med Res Case Reports The ongoing global administration of vaccines for coronavirus disease 2019 (COVID-19) means that increasing numbers of patients are likely to present with post-vaccination complications. We describe the first reported case of neuralgic amyotrophy (NA) involving the lumbosacral plexus occurring after AstraZeneca COVID-19 vaccination. The patient presented with acute-onset leg paralysis following administration of the vaccine. Based on the clinical, electrodiagnostic, and radiologic findings, the patient was diagnosed with post-vaccination NA. We speculate that the COVID-19 vaccine elicited an immune-mediated inflammatory response to the injected antigen due to inflammatory immunity in a patient with predisposed susceptibility to NA. SAGE Publications 2021-11-24 /pmc/articles/PMC8649466/ /pubmed/34816739 http://dx.doi.org/10.1177/03000605211056783 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by-nc/4.0/Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Case Reports
Kim, Se Il
Seok, Hung Youl
Yi, Jaehyuck
Cho, Jang Hyuk
Leg paralysis after AstraZeneca COVID-19 vaccination diagnosed as neuralgic amyotrophy of the lumbosacral plexus: a case report
title Leg paralysis after AstraZeneca COVID-19 vaccination diagnosed as neuralgic amyotrophy of the lumbosacral plexus: a case report
title_full Leg paralysis after AstraZeneca COVID-19 vaccination diagnosed as neuralgic amyotrophy of the lumbosacral plexus: a case report
title_fullStr Leg paralysis after AstraZeneca COVID-19 vaccination diagnosed as neuralgic amyotrophy of the lumbosacral plexus: a case report
title_full_unstemmed Leg paralysis after AstraZeneca COVID-19 vaccination diagnosed as neuralgic amyotrophy of the lumbosacral plexus: a case report
title_short Leg paralysis after AstraZeneca COVID-19 vaccination diagnosed as neuralgic amyotrophy of the lumbosacral plexus: a case report
title_sort leg paralysis after astrazeneca covid-19 vaccination diagnosed as neuralgic amyotrophy of the lumbosacral plexus: a case report
topic Case Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8649466/
https://www.ncbi.nlm.nih.gov/pubmed/34816739
http://dx.doi.org/10.1177/03000605211056783
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