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Methodological Rigor and Temporal Trends of Cardiovascular Medicine Meta‐Analyses in Highest‐Impact Journals

BACKGROUND: Well‐conducted meta‐analyses are considered to be at the top of the evidence‐based hierarchy pyramid, with an expansion of these publications within the cardiovascular research arena. There are limited data evaluating the trends and quality of such publications. The objective of this stu...

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Autores principales: Mahtta, Dhruv, Altibi, Ahmed, Gad, Mohamed M., Samara, Amjad, Barakat, Amr F., Bagur, Rodrigo, Mansoor, Hend, Jneid, Hani, Virani, Salim S., Mamas, Mamas A., Masri, Ahmad, Elgendy, Islam Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8649500/
https://www.ncbi.nlm.nih.gov/pubmed/34533035
http://dx.doi.org/10.1161/JAHA.121.021367
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author Mahtta, Dhruv
Altibi, Ahmed
Gad, Mohamed M.
Samara, Amjad
Barakat, Amr F.
Bagur, Rodrigo
Mansoor, Hend
Jneid, Hani
Virani, Salim S.
Mamas, Mamas A.
Masri, Ahmad
Elgendy, Islam Y.
author_facet Mahtta, Dhruv
Altibi, Ahmed
Gad, Mohamed M.
Samara, Amjad
Barakat, Amr F.
Bagur, Rodrigo
Mansoor, Hend
Jneid, Hani
Virani, Salim S.
Mamas, Mamas A.
Masri, Ahmad
Elgendy, Islam Y.
author_sort Mahtta, Dhruv
collection PubMed
description BACKGROUND: Well‐conducted meta‐analyses are considered to be at the top of the evidence‐based hierarchy pyramid, with an expansion of these publications within the cardiovascular research arena. There are limited data evaluating the trends and quality of such publications. The objective of this study was to evaluate the methodological rigor and temporal trends of cardiovascular medicine‐related meta‐analyses published in the highest impact journals. METHODS AND RESULTS: Using the Medline database, we retrieved cardiovascular medicine‐related systematic reviews and meta‐analyses published in The New England Journal of Medicine, The Lancet, Journal of the American Medical Association, The British Medical Journal, Annals of Internal Medicine, Circulation, European Heart Journal, and Journal of American College of Cardiology between January 1, 2012 and December 31, 2018. Among 6406 original investigations published during the study period, meta‐analyses represented 422 (6.6%) articles, with an annual decline in the proportion of published meta‐analyses (8.7% in 2012 versus 4.6% in 2018, P (trend)=0.002). A substantial number of studies failed to incorporate elements of Preferred Reporting Items for Systematic Reviews and Meta‐Analyses or Meta‐Analysis of Observational Studies in Epidemiology guidelines (51.9%) and only a minority of studies (10.4%) were registered in PROSPERO (International Prospective Register of Systematic Reviews). Fewer manuscripts failed to incorporate the Preferred Reporting Items for Systematic Reviews and Meta‐Analyses or Meta‐Analysis of Observational Studies in Epidemiology elements over time (60.2% in 2012 versus 40.0% in 2018, P (trend)<0.001) whereas the number of meta‐analyses registered at PROSPERO has increased (2.4% in 2013 versus 17.5% in 2018, P (trend)<0.001). CONCLUSIONS: The proportion of cardiovascular medicine‐related meta‐analyses published in the highest impact journals has declined over time. Although there is an increasing trend in compliance with quality‐based guidelines, the overall compliance remains low.
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spelling pubmed-86495002021-12-20 Methodological Rigor and Temporal Trends of Cardiovascular Medicine Meta‐Analyses in Highest‐Impact Journals Mahtta, Dhruv Altibi, Ahmed Gad, Mohamed M. Samara, Amjad Barakat, Amr F. Bagur, Rodrigo Mansoor, Hend Jneid, Hani Virani, Salim S. Mamas, Mamas A. Masri, Ahmad Elgendy, Islam Y. J Am Heart Assoc Original Research BACKGROUND: Well‐conducted meta‐analyses are considered to be at the top of the evidence‐based hierarchy pyramid, with an expansion of these publications within the cardiovascular research arena. There are limited data evaluating the trends and quality of such publications. The objective of this study was to evaluate the methodological rigor and temporal trends of cardiovascular medicine‐related meta‐analyses published in the highest impact journals. METHODS AND RESULTS: Using the Medline database, we retrieved cardiovascular medicine‐related systematic reviews and meta‐analyses published in The New England Journal of Medicine, The Lancet, Journal of the American Medical Association, The British Medical Journal, Annals of Internal Medicine, Circulation, European Heart Journal, and Journal of American College of Cardiology between January 1, 2012 and December 31, 2018. Among 6406 original investigations published during the study period, meta‐analyses represented 422 (6.6%) articles, with an annual decline in the proportion of published meta‐analyses (8.7% in 2012 versus 4.6% in 2018, P (trend)=0.002). A substantial number of studies failed to incorporate elements of Preferred Reporting Items for Systematic Reviews and Meta‐Analyses or Meta‐Analysis of Observational Studies in Epidemiology guidelines (51.9%) and only a minority of studies (10.4%) were registered in PROSPERO (International Prospective Register of Systematic Reviews). Fewer manuscripts failed to incorporate the Preferred Reporting Items for Systematic Reviews and Meta‐Analyses or Meta‐Analysis of Observational Studies in Epidemiology elements over time (60.2% in 2012 versus 40.0% in 2018, P (trend)<0.001) whereas the number of meta‐analyses registered at PROSPERO has increased (2.4% in 2013 versus 17.5% in 2018, P (trend)<0.001). CONCLUSIONS: The proportion of cardiovascular medicine‐related meta‐analyses published in the highest impact journals has declined over time. Although there is an increasing trend in compliance with quality‐based guidelines, the overall compliance remains low. John Wiley and Sons Inc. 2021-09-17 /pmc/articles/PMC8649500/ /pubmed/34533035 http://dx.doi.org/10.1161/JAHA.121.021367 Text en © 2021 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Original Research
Mahtta, Dhruv
Altibi, Ahmed
Gad, Mohamed M.
Samara, Amjad
Barakat, Amr F.
Bagur, Rodrigo
Mansoor, Hend
Jneid, Hani
Virani, Salim S.
Mamas, Mamas A.
Masri, Ahmad
Elgendy, Islam Y.
Methodological Rigor and Temporal Trends of Cardiovascular Medicine Meta‐Analyses in Highest‐Impact Journals
title Methodological Rigor and Temporal Trends of Cardiovascular Medicine Meta‐Analyses in Highest‐Impact Journals
title_full Methodological Rigor and Temporal Trends of Cardiovascular Medicine Meta‐Analyses in Highest‐Impact Journals
title_fullStr Methodological Rigor and Temporal Trends of Cardiovascular Medicine Meta‐Analyses in Highest‐Impact Journals
title_full_unstemmed Methodological Rigor and Temporal Trends of Cardiovascular Medicine Meta‐Analyses in Highest‐Impact Journals
title_short Methodological Rigor and Temporal Trends of Cardiovascular Medicine Meta‐Analyses in Highest‐Impact Journals
title_sort methodological rigor and temporal trends of cardiovascular medicine meta‐analyses in highest‐impact journals
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8649500/
https://www.ncbi.nlm.nih.gov/pubmed/34533035
http://dx.doi.org/10.1161/JAHA.121.021367
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