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Aging and Hypercholesterolemia Differentially Affect the Unfolded Protein Response in the Vasculature of ApoE (−/−) Mice

BACKGROUND: Persistent activation of endoplasmic reticulum stress and the unfolded protein response (UPR) induces vascular cell apoptosis, contributing to atherogenesis. Aging and hypercholesterolemia are 2 independent proatherogenic factors. How they affect vascular UPR signaling remains unclear. M...

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Detalles Bibliográficos
Autores principales:	Zhou, Yuxiang, Wan, Xueping, Seidel, Kerstin, Zhang, Mo, Goodman, Jena B., Seta, Francesca, Hamburg, Naomi, Han, Jingyan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2021
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8649520/ https://www.ncbi.nlm.nih.gov/pubmed/34533042 http://dx.doi.org/10.1161/JAHA.120.020441

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