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Vitamin A cycle byproducts explain retinal damage and molecular changes thought to initiate retinal degeneration

In the most prevalent retinal diseases, including Stargardt disease and age-related macular degeneration (AMD), byproducts of vitamin A form in the retina abnormally during the vitamin A cycle. Despite evidence of their toxicity, whether these vitamin A cycle byproducts contribute to retinal disease...

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Detalles Bibliográficos
Autores principales: Zhang, Dan, Mihai, Doina M., Washington, Ilyas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8649638/
https://www.ncbi.nlm.nih.gov/pubmed/34842275
http://dx.doi.org/10.1242/bio.058600