Liver sphingomyelin synthase 1 deficiency causes steatosis, steatohepatitis, fibrosis, and tumorigenesis: An effect of glucosylceramide accumulation

Glucosylceramide (GluCer) was accumulated in sphingomyelin synthase 1 (SMS1) but not SMS2 deficient mouse tissues. In current study, we studied GluCer accumulation-mediated metabolic consequences. Livers from liver-specific Sms1/global Sms2 double-knockout (dKO) exhibited severe steatosis under a hi...

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Detalles Bibliográficos
Autores principales: Li, Zhiqiang, Chiang, Yeun-po, He, Mulin, Worgall, Tilla S., Zhou, Hongwen, Jiang, Xian-Cheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8649732/
https://www.ncbi.nlm.nih.gov/pubmed/34927020
http://dx.doi.org/10.1016/j.isci.2021.103449

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8649732/
https://www.ncbi.nlm.nih.gov/pubmed/34927020
http://dx.doi.org/10.1016/j.isci.2021.103449

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