Plasma Membrane Anchoring and Gag:Gag Multimerization on Viral RNA Are Critical Properties of HIV-1 Gag Required To Mediate Efficient Genome Packaging

Human immunodeficiency virus type 1 (HIV-1) Gag selects and packages the HIV RNA genome during virus assembly. However, HIV-1 RNA constitutes only a small fraction of the cellular RNA. Although Gag exhibits a slight preference to viral RNA, most of the cytoplasmic Gag proteins are associated with ce...

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Detalles Bibliográficos
Autores principales: Duchon, Alice, Santos, Steven, Chen, Jianbo, Brown, Matthew, Nikolaitchik, Olga A., Tai, Sheldon, Chao, Jeffrey A., Freed, Eric O., Pathak, Vinay K., Hu, Wei-Shau
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8649766/
https://www.ncbi.nlm.nih.gov/pubmed/34872357
http://dx.doi.org/10.1128/mbio.03254-21

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