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Systemic Supplementation of Collagen VI by Neonatal Transplantation of iPSC-Derived MSCs Improves Histological Phenotype and Function of Col6-Deficient Model Mice

Collagen VI is distributed in the interstitium and is secreted mainly by mesenchymal stromal cells (MSCs) in skeletal muscle. Mutations in COL6A1-3 genes cause a spectrum of COL6-related myopathies. In this study, we performed a systemic transplantation study of human-induced pluripotent stem cell (...

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Detalles Bibliográficos
Autores principales:	Harada, Aya, Goto, Megumi, Kato, Atsuya, Takenaka-Ninagawa, Nana, Tanaka, Akito, Noguchi, Satoru, Ikeya, Makoto, Sakurai, Hidetoshi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Cell and Developmental Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8649773/ https://www.ncbi.nlm.nih.gov/pubmed/34888314 http://dx.doi.org/10.3389/fcell.2021.790341

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