A Two-Color Haploid Genetic Screen Identifies Novel Host Factors Involved in HIV-1 Latency

To identify novel host factors as putative targets to reverse HIV-1 latency, we performed an insertional mutagenesis genetic screen in a latent HIV-1 infected pseudohaploid KBM7 cell line (Hap-Lat). Following mutagenesis, insertions were mapped to the genome, and bioinformatic analysis resulted in t...

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Detalles Bibliográficos
Autores principales: Röling, Michael, Mollapour Sisakht, Mahsa, Ne, Enrico, Moulos, Panagiotis, Crespo, Raquel, Stoszko, Mateusz, De Crignis, Elisa, Bodmer, Helen, Kan, Tsung Wai, Akbarzadeh, Maryam, Harokopos, Vaggelis, Hatzis, Pantelis, Palstra, Robert-Jan, Mahmoudi, Tokameh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8649776/
https://www.ncbi.nlm.nih.gov/pubmed/34872356
http://dx.doi.org/10.1128/mBio.02980-21

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