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An Early-Onset Advanced Rectal Cancer Patient With Increased KRAS Gene Copy Number Showed A Primary Resistance to Cetuximab in Combination With Chemotherapy: A Case Report

Mutations in KRAS (codon 12/13), NRAS, BRAF (V600E), and amplification of ERBB2 and MET account for 70–80% of anti-epidermal growth factor receptor (EGFR) monoclonal antibody primary resistance. However, the list of anti-EGFR monoclonal antibody primary resistance biomarkers is still incomplete. Her...

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Detalles Bibliográficos
Autores principales:	Fang, Tian, Liang, Tingting, Wang, Yizhuo, Wu, Haitao, Liu, Shuhan, Xie, Linying, Zhang, Zhihao, Liang, Jiaying, Yao, Cheng, Tan, Yehui, Wang, Chang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Oncology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8649836/ https://www.ncbi.nlm.nih.gov/pubmed/34888240 http://dx.doi.org/10.3389/fonc.2021.755578

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