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Interaction between the inflammasome and commensal microorganisms in gastrointestinal health and disease

The inflammasome is a cytosolic multiprotein complex that plays a crucial role in inflammation and cell death. The sensor proteins in the inflammasome complex detect various microbial and endogenous stimuli, leading to subsequent caspase activation. The activation of caspases results in the maturati...

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Autores principales: Watanabe, Daisuke, Guo, Yijie, Kamada, Nobuhiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8649886/
https://www.ncbi.nlm.nih.gov/pubmed/34705319
http://dx.doi.org/10.15252/emmm.202013452
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author Watanabe, Daisuke
Guo, Yijie
Kamada, Nobuhiko
author_facet Watanabe, Daisuke
Guo, Yijie
Kamada, Nobuhiko
author_sort Watanabe, Daisuke
collection PubMed
description The inflammasome is a cytosolic multiprotein complex that plays a crucial role in inflammation and cell death. The sensor proteins in the inflammasome complex detect various microbial and endogenous stimuli, leading to subsequent caspase activation. The activation of caspases results in the maturation of pro‐inflammatory cytokines IL‐1β and IL‐18 or pyroptosis. Inflammasome dysfunction is associated with the pathogenesis of various diseases, including autoimmune disease and cancer. It appears that the interactions between the gut microbiota and the inflammasome play crucial roles in the gastrointestinal tract. The gut microbiota induces the expression and activation of inflammasome proteins, which contribute to both homeostasis and disease in the gut. Likewise, although controversial, mounting evidence suggests that inflammasome activation can modulate the composition of the gut microbiota, which, in turn, affects disease progression. In this review, we summarize the current concepts and recent insights linking the inflammasome and gut commensal microorganisms. We describe how the reciprocal interaction between the inflammasome and the commensal microbiota relates to physiological and pathophysiological consequences in the host.
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spelling pubmed-86498862021-12-20 Interaction between the inflammasome and commensal microorganisms in gastrointestinal health and disease Watanabe, Daisuke Guo, Yijie Kamada, Nobuhiko EMBO Mol Med Reviews The inflammasome is a cytosolic multiprotein complex that plays a crucial role in inflammation and cell death. The sensor proteins in the inflammasome complex detect various microbial and endogenous stimuli, leading to subsequent caspase activation. The activation of caspases results in the maturation of pro‐inflammatory cytokines IL‐1β and IL‐18 or pyroptosis. Inflammasome dysfunction is associated with the pathogenesis of various diseases, including autoimmune disease and cancer. It appears that the interactions between the gut microbiota and the inflammasome play crucial roles in the gastrointestinal tract. The gut microbiota induces the expression and activation of inflammasome proteins, which contribute to both homeostasis and disease in the gut. Likewise, although controversial, mounting evidence suggests that inflammasome activation can modulate the composition of the gut microbiota, which, in turn, affects disease progression. In this review, we summarize the current concepts and recent insights linking the inflammasome and gut commensal microorganisms. We describe how the reciprocal interaction between the inflammasome and the commensal microbiota relates to physiological and pathophysiological consequences in the host. John Wiley and Sons Inc. 2021-10-27 2021-12-07 /pmc/articles/PMC8649886/ /pubmed/34705319 http://dx.doi.org/10.15252/emmm.202013452 Text en © 2021 The Authors. Published under the terms of the CC BY 4.0 license https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Reviews
Watanabe, Daisuke
Guo, Yijie
Kamada, Nobuhiko
Interaction between the inflammasome and commensal microorganisms in gastrointestinal health and disease
title Interaction between the inflammasome and commensal microorganisms in gastrointestinal health and disease
title_full Interaction between the inflammasome and commensal microorganisms in gastrointestinal health and disease
title_fullStr Interaction between the inflammasome and commensal microorganisms in gastrointestinal health and disease
title_full_unstemmed Interaction between the inflammasome and commensal microorganisms in gastrointestinal health and disease
title_short Interaction between the inflammasome and commensal microorganisms in gastrointestinal health and disease
title_sort interaction between the inflammasome and commensal microorganisms in gastrointestinal health and disease
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8649886/
https://www.ncbi.nlm.nih.gov/pubmed/34705319
http://dx.doi.org/10.15252/emmm.202013452
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