Computational Construction of a Single-Chain Bi-Paratopic Antibody Allosterically Inhibiting TCR-Staphylococcal Enterotoxin B Binding

Staphylococcal enterotoxin B (SEB) simultaneously crosslinks MHC class II antigen and TCR, promoting proliferation of T cells and releasing a large number of toxic cytokines. In this report, we computationally examined the possibility of using a single-chain biparatopic bispecific antibody to target...

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Detalles Bibliográficos
Autores principales: Bai, Ganggang, Ge, Yanhong, Su, Yuhong, Chen, Shuo, Zeng, Xingcheng, Lu, Huixia, Ma, Buyong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8649926/
https://www.ncbi.nlm.nih.gov/pubmed/34887850
http://dx.doi.org/10.3389/fimmu.2021.732938

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8649926/
https://www.ncbi.nlm.nih.gov/pubmed/34887850
http://dx.doi.org/10.3389/fimmu.2021.732938

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