Metal-Free Solvent Promoted Oxidation of Benzylic Secondary Amines to Nitrones with H(2)O(2)

[Image: see text] An environmentally benign protocol for the generation of nitrones from benzylic secondary amines via catalyst-free oxidation of secondary amines using H(2)O(2) in MeOH or CH(3)CN is described. This methodology provides a selective access to a variety of C-aryl nitrones in yields of...

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Autores principales: Granato, Álisson Silva, Amarante, Giovanni Wilson, Adrio, Javier
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8650016/
https://www.ncbi.nlm.nih.gov/pubmed/34528787
http://dx.doi.org/10.1021/acs.joc.1c01888
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author Granato, Álisson Silva
Amarante, Giovanni Wilson
Adrio, Javier
author_facet Granato, Álisson Silva
Amarante, Giovanni Wilson
Adrio, Javier
author_sort Granato, Álisson Silva
collection PubMed
description [Image: see text] An environmentally benign protocol for the generation of nitrones from benzylic secondary amines via catalyst-free oxidation of secondary amines using H(2)O(2) in MeOH or CH(3)CN is described. This methodology provides a selective access to a variety of C-aryl nitrones in yields of 60 to 93%. Several studies have been performed to shed light on the reaction mechanism and the role of the solvent.
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spelling pubmed-86500162021-12-08 Metal-Free Solvent Promoted Oxidation of Benzylic Secondary Amines to Nitrones with H(2)O(2) Granato, Álisson Silva Amarante, Giovanni Wilson Adrio, Javier J Org Chem [Image: see text] An environmentally benign protocol for the generation of nitrones from benzylic secondary amines via catalyst-free oxidation of secondary amines using H(2)O(2) in MeOH or CH(3)CN is described. This methodology provides a selective access to a variety of C-aryl nitrones in yields of 60 to 93%. Several studies have been performed to shed light on the reaction mechanism and the role of the solvent. American Chemical Society 2021-09-16 2021-10-01 /pmc/articles/PMC8650016/ /pubmed/34528787 http://dx.doi.org/10.1021/acs.joc.1c01888 Text en © 2021 American Chemical Society https://creativecommons.org/licenses/by/4.0/Permits the broadest form of re-use including for commercial purposes, provided that author attribution and integrity are maintained (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Granato, Álisson Silva
Amarante, Giovanni Wilson
Adrio, Javier
Metal-Free Solvent Promoted Oxidation of Benzylic Secondary Amines to Nitrones with H(2)O(2)
title Metal-Free Solvent Promoted Oxidation of Benzylic Secondary Amines to Nitrones with H(2)O(2)
title_full Metal-Free Solvent Promoted Oxidation of Benzylic Secondary Amines to Nitrones with H(2)O(2)
title_fullStr Metal-Free Solvent Promoted Oxidation of Benzylic Secondary Amines to Nitrones with H(2)O(2)
title_full_unstemmed Metal-Free Solvent Promoted Oxidation of Benzylic Secondary Amines to Nitrones with H(2)O(2)
title_short Metal-Free Solvent Promoted Oxidation of Benzylic Secondary Amines to Nitrones with H(2)O(2)
title_sort metal-free solvent promoted oxidation of benzylic secondary amines to nitrones with h(2)o(2)
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8650016/
https://www.ncbi.nlm.nih.gov/pubmed/34528787
http://dx.doi.org/10.1021/acs.joc.1c01888
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AT adriojavier metalfreesolventpromotedoxidationofbenzylicsecondaryaminestonitroneswithh2o2

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