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Predictive role of endothelial cell activation in cytokine release syndrome after chimeric antigen receptor T cell therapy for acute lymphoblastic leukaemia

CD19‐target chimeric antigen receptor (CAR)‐T cell therapy is highly effective for relapsed/refractory (R/R) acute lymphoblastic leukaemia (ALL), but is often complicated by cytokine release syndrome (CRS), which is potentially life‐threatening. Endothelial cells are the core regulator of CRS in man...

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Detalles Bibliográficos
Autores principales: Hong, Fei, Shi, Ming, Cao, Jiang, Wang, Ying, Gong, Yanqing, Gao, Hui, Li, Zhenyu, Zheng, Junnian, Zeng, Lingyu, He, Aili, Xu, Kailin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8650023/
https://www.ncbi.nlm.nih.gov/pubmed/34734474
http://dx.doi.org/10.1111/jcmm.17029